Compositions and methods for the inhibition of MUC-5 mucin gene

Details Compositions and methods for the inhibition of MUC-5 mucin gene Compositions and methods for the inhibition of MUC-5 mucin gene

1999-02-11

2000-10-24

Zitomer, Stephanie W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4353201, 435325, 536 231, 536 241, 536 242, 536 243, C12Q 168, C12N 500, C12N 1500, C07H 2102, C07H 2104

Patent

active

061365394

ABSTRACT:
The invention relates to methods for identifying inhibitors of mucin production, methods for inhibiting mucin production and methods for treating airway diseases, such as cystic fibrosis, chronic bronchitis, bronchial pneumonia and asthma. Compositions are provided for use in the method comprising reporter gene constructs which are inducible by mucomones.

REFERENCES:
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Gendler S et al., Annu. Rev. Physiol. 57:607-634 (1995).
Li et al., Transcriptional activation of mucin by Pseudomonas aeruginosa lipoplysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc. Natl. Acad. Sci. USA, vol. 94, pp. 967-972, Mar. 1997.
Meerzaman et al., Cloning and Analysis of cDNA encoding a major airway glycoprotein, human tracheobronchial mucin (MUC5). Journal of Biological Chemistry, vol. 269, No. 17, pp. 12932-12939, Mar. 1994.
Duperat et al., Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucine genes? Biochemical Journal, vol. 305, pp. 211-219, Mar. 1997.
Boucher et al., "Mucoid Pseudomonas aeruginosa in Cystic Fibrosis: Characterization of muc Mutations in Clinical Isolates and Analysis of Clearance in a Mouse Model of Respiratory Infection," Infection and Immunity, vol. 65, No. 9, pp. 3838-3846, 1997 (A).
Li et al., "Cloning of the Amino-terminal and 5'-Flanking region of the Human MUC5AC Mucin Gene and Transcription Up-regulation by Bacterial Exoproducts," J. Bio. Chem., vol. 273, No. 12, pp. 6812-6820, 1998 (Y).

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