Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2003-02-07
2008-12-30
Rawlings, Stephen L (Department: 1643)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S023500, C435S004000
Reexamination Certificate
active
07470509
ABSTRACT:
The present invention is directed to the identification of markers that can be used to determine whether ovarian cancer is sensitive or resistant to a therapeutic agent. In particular, the present invention is directed to the use of certain combinations of markers, wherein the expression of the markers correlates with sensitivity or resistance to a therapeutic agent. Thus, by examining the expression of the individual markers of a marker set, also referred to as the expression profile of the marker set, it is possible to determine whether a therapeutic agent, or combination of agents, will be most likely to reduce the growth rate of the ovarian cancer.
REFERENCES:
patent: 6258536 (2001-07-01), Oliner et al.
Engblom et al. (Anticancer Res. Jul.-Aug. 1997; 17 (4A): 2475-2479).
Gyorffy et al. (Oncogene. 2005; 24: 7542-751).
Duan et al. (Cancer Chemother. Pharmacol. Mar. 2005; 55 (3): 277-285).
Kolfschoten et al. (Br. J. Cancer. 2000; 83 (7): 921-927).
Hannermann et al. (J. Clin. Oncol. May 2005; 23 (15): 3331-3342).
Hogberg et al. (Acta Oncologica. 2001; 40 (2/3): 340-360).
Hough et al. (Cancer Res. Nov. 15, 2000; 60: 6281-6287).
Tewari et al. (Cur. Oncol. Rep. 1999; 1: 77-84).
Xiong et al. (Mol. Genetics Metab. 2001; 73: 239-247).
Nguyen et al. (Bioinformatics. 2002; 18 (1): 39-50).
Hagopian et al. (Clin. Cancer Res. Mar. 1999; 5: 655-63).
Byvatov et al. (Appl. Bioinformatics. 203; 2 (2): 67-77).
Somorjai et al. (Bioinformatics. 2003; 19 (12): 1484-1491).
Hartmann et al. (Clin. Cancer Res. Mar. 15, 2005; 11: 2149-2155.
Spentzos et al. (J. Clin. Oncol. Nov. 1, 2005; 23 (31): 7911-7918).
Goto et al. (Oncol. Rep. 2006; 15: 1265-1271).
Komatsu et al. (Mol. Cancer Ther. Mar. 2006; 5 (3): 767-775).
Lavarino et al. (J. Clin. Oncol. 2000; 18 (23): 3936-3945).
Ripley, B.D., “Pattern Recognition and Neural Networks,”Cambridge University Press, (1996), pp. 91-93, 191, 365.
Bast, Jr. Robert C.
Clark Edwin A.
Damokosh Andrew I.
Hartmann Lynn
Iartchouk Natalia
Millennium Pharmaceuticals Inc.
Rawlings Stephen L
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