Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-01-11
2011-01-11
Navarro, Mark (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C435S975000
Reexamination Certificate
active
07868139
ABSTRACT:
Compositions and methods for the therapy and diagnosis of immune-mediated inflammatory diseases, including inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention or treatment of immune-mediated inflammatory disease.
REFERENCES:
patent: 6821739 (2004-11-01), Braun
patent: 7009042 (2006-03-01), Skeiky
patent: 7361733 (2008-04-01), Hershberg
patent: 2002/0039599 (2002-04-01), Lin
patent: 2002/0044938 (2002-04-01), Fox
patent: 2003/0003516 (2003-01-01), Robinson
patent: 2003/0031625 (2003-02-01), Lin
patent: 2005/0208597 (2005-09-01), Chan
patent: WO 91/18926 (1991-12-01), None
patent: WO 03/053220 (2003-07-01), None
Beckwith J, Cong Y, Sundberg JP, Elson CO, Leiter EH. (2005) Cdcsl, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens. Gastroenterology. 129(5): 1473-1784.
Brandwein SL, McCabe RP, Cong Y, Waites KB, Ridwan BU, Dean PA, Ohkusa T, Birkenmeier EH, Sundberg JP, Elson CO. (1997) Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J Immunol. 159(1): 44-52.
Cohavy O, Harth G, Horwitz M, Eggena M, Landers C, Sutton C, Targan SR, Braun J. (1999) Identification of a novel mycobacterial histone H1 homologue (HupB) as an antigenic target of pANCA monoclonal antibody and serum immunoglobulin A from patients with Crohn's disease. Infect Immun. 67(12): 6510-6517.
Cong Y, Brandwein SL, McCabe RP, Lazenby A, Birkenmeier EH, Sundberg JP, Elson CO. (1998) CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med. 187(6): 855-864.
Cong Y, Konrad A, Iqbal N, Hatton RD, Weaver CT, Elson CO. (2005) Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome function. J Immunol. 174(5): 2787-2795.
Cong Y, Weaver CT, Elson CO. (1997) The mucosal adjuvanticity of cholera toxin involves enhancement of costimulatory activity by selective up-regulation of B7.2 expression. J Immunol. 159(11): 5301-5308.
Cuadros C, Lopez-Hernandez FJ, Dominguez AL, McClelland M, Lustgarten J. (2004) Flagellin fusion proteins as adjuvants or vaccines induce specific immune responses. Infect Immun. 72(5): 2810-2816.
Crotty S, Aubert RD, Glidewell J, Ahmed R. (2004) Tracking human antigen-specific memory B cells: a sensitive and generalized ELISPOT system. J Immunol Methods. 286(1-2): 111-122.
Fontenot JD, Gavin MA, Rudensky AY. (2003) Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 4(4):330-36.
Hanauer SB. (2003) Genetics of IBD: Clinical Relevance. Medscape Gasteroenterology. (Available at http://cme.medscape.com/viewarticle/456992.).
Hori S, Nomura T, Sakaguchi S. (2003) Control of regulatory T cell development by the transcription factor Foxp3. Science. 299(5609): 1057-61.
Iqbal N, Oliver JR, Wagner FH, Lazenby AS, Elson CO, Weaver CT. (2002) T helper 1 and T helper 2 cells are pathogenic in an antigen-specific model of colitis. J Exp Med. 195(1): 71-84.
Kanauchi O, Mitsuyama K, Araki Y, Andoh A. (2003) Modification of intestinal flora in the treatment of inflammatory bowel disease. Curr Pharm Des. 9(4): 333-346.
Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, Targan SR, Fort M, Hershberg RM. (2004) Bacterial Flagellin is a dominant antigen in Crohn disease. J Clin Invest. 113(9): 1296-306.
McSorley SJ, Ehst BD, Yu Y, Gewirtz AT. (2002) Bacterial Flagellin is an effective adjuvant for CD4+ T cells in vivo. J Immunol. 169(7): 3914-3919.
Rautava S, Isolauri E. (2002) The development of gut immune responses and gut microbiota: effects of probiotics in prevention and treatment of allergic disease. Curr Issues Intest Microbiol. 3(1): 15-22.
Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Fournel S, Fong D, Genovese MC, de Vegvar HE, Skriner K, Hirschberg DL, Morris RI, Muller S, Pruijn GJ, van Venrooij WJ, Smolen JS, Brown PO, Steinman L, Utz PJ. (2002) Autoantigen microarrays for multiplex characterization of autoantibody responses. Nat Med. 8(3): 295-301.
Sakaguchi S. (2003) The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery. J Clin Invest. 112(9): 1310-12.
Skeiky YA, Lodes MJ, Guderian JA, Mohamath R, Bement T, Alderson MR, Reed SG. (1999) Cloning, expression, and immunological evaluation of two putative secreted serine protease antigens of Mycobacterium tuberculosis. Infect Immun. 67(8): 3998-4007.
Stoute JA, Slaoui M, Heppner DG, Momin P, Kester KE, Desmons P, Wellde BT, Garcon N, Krzych U, Marchand M. (1997) A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. N Engl J Med. 336(2): 86-91.
Tannock GW, Sartor RB, Walter J, Lerner A. (2005) Cloning the Gut Metagenome: A Strategy to Detect Pro-inflammatory Substances Produced by Intestinal Bacterial, Abstract presented at the 3thAnnual BMRP Investigator Meeting (Feb. 24-25, 2005).
Targan SR, Landers CJ, Yang H, Lodes MJ, Cong Y, Papadakis KA, Vasiliauskas E, Elson CO, Hershberg RM. (2005) Antibodies to CBirl flagelin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 128(7): 2020-2028.
The Food, GI-tract Functionality and Human Health Cluster—PROEUHEALTH. Workshop 4—Brussels, Belgium (Mar. 10-11, 2005).
Traggiai E, Becker S, Subbarao K, Kolesnikova L, Uematsu Y, Gismondo MR, Murphy BR, Rappuoli R, Lanzavecchia A. (2004) An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus. Nat Med. 10(8): 871-75.
Yoshimura S, Bondeson J, Foxwell BM, Brennan FM, Feldmann M, (2001) Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. Int Immunol. 13(5): 675-683.
Zajac AJ, Blattman JN, Murali-Krishna K, Sourdive DJ, Suresh M, Altman JD, Ahmed R. (1998) Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med. 188(12): 2205-2213.
International Search Report dated Aug. 8, 2008 for PCT/US2007/060996 (published as WO 2007/087576 on Aug. 2, 2007) naming Elson et al. as inventors and The UAB Research Foundation as the Applicant.
International Preliminary Report on Patentability including Written Opinion dated Sep. 9, 2008 for PCT/US2007/060996 (published as WO 2007/087576 on Aug. 2, 2007) naming Elson et al. as inventors and The UAB Research Foundation as the Applicant.
Cong Y, Hershberg RM, Landers CJ, Targan SR, Elson CO. (2004) Seroreactivity to a cluster of commensal flagellin in Crohn's disease Annual Meeting of the American Gastroenterological Association, May 14-19, 2005, in Chicago, IL.
Papadakis KA, Yang H, Ippoliti A, Elson CO, Hershberg RM, Vasiliauskas EA, Fleshner PR, Abreu MT, Taylor K, Rotter JI, Landers C, Targan SR. (2005) Anti-Flagellin (CBirl) Phenotypic and Genetic Chron's Disease Associations Annual Meeting of the American Gastroenterological Association, May 14-19, 2005, in Chicago, IL.
Dubinsky M, Mei L, Dutridge D, Picornell Y, Landers C, Farrior S, Wrobel I, Quios A, Christie D, Wahbeh G, Bahar R, Vasiliauskus E, Grill B, Silber G, Israel D, Kelts D, Shah P, Pietzak M, Dallazadeh S, Hershberg R, Elson C, Targan S, Taylor K, Rotter J, Yang HY. (2005) Annual Meeting of the American Gastroenterological Association, May 14-19, 2005, in Chicago, IL.
Cong Y, Lodes MJ, Hershberg RM, Elson CO. (2004) CBirl flagellin is a dominant enteric bacterial antigen that activates pathogenic CD+4 Thl cell responses in vivo. (2004) Annual Meeting of the American Gastroenterological Association, May
Cong Yingzi
Elson Charles O.
Ballard Spahr LLP
Navarro Mark
UAB Research Foundation
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