Compositions and methods for the delivery of drugs by platelets

Details Compositions and methods for the delivery of drugs by platelets Compositions and methods for the delivery of drugs by platelets

1994-08-05

1998-06-02

Carlson, Karen C.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

435215, 435212, A61K 3849, C12N 972

Patent

active

057595429

ABSTRACT:
A fusion drug including an isolated portion of the A-chain of a urokinase-type plasminogen activator linked to a drug, wherein the A-chain portion binds stably to an outer membrane of a platelet. The T.sub.1/2 of the fusion drug in plasma is thereby increased to about 4 to 5 days, and the fusion drug is automatically targeted to forming thrombi and sites of vascular injury. The fusion drug can thus be used to treat cardiovascular diseases, e.g., as adjunctive therapy to inhibit reocclusions in a patient after thrombolytic therapy or angioplasty.

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