Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing
Patent
1995-05-25
1997-08-05
Ziska, Suzanne E.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
424 932, 424 9321, 424 933, 424 937, 4351723, C12N 1500, C12N 500, A01N 6300
Patent
active
056539754
ABSTRACT:
This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within a mammalian host. The novel capsules of this invention are biocompatible and are easily retrievable. This invention specifically provides improved methods and compositions which utilize cells transfected with recombinant DNA molecules comprising DNA sequences coding for biologically active molecules operatively linked to promoters that are not subject to down regulation in vivo upon implantation into a mammalian host. Furthermore, the methods of this invention allow for the long-term, stable and efficacious delivery of biologically active molecules from living cells to specific sites within a given mammal. In addition, this invention provides a general means for maintaining, for extended periods of time, the in vivo expression of transgenes.
REFERENCES:
patent: 3093831 (1963-06-01), Jordan
patent: 3615024 (1971-10-01), Michaels
patent: 4298002 (1981-11-01), Ronel et al.
patent: 4352883 (1982-10-01), Lim
patent: 4353888 (1982-10-01), Sefton
patent: 4409331 (1983-10-01), Lim
patent: 4470461 (1984-09-01), Stadd
patent: 4686098 (1987-08-01), Kopchick et al.
patent: 4689293 (1987-08-01), Goosen et al.
patent: 4749620 (1988-06-01), Rha et al.
patent: 4753635 (1988-06-01), Sagen et al.
patent: 4789550 (1988-12-01), Hommel et al.
patent: 4806355 (1989-02-01), Goosen
patent: 4868121 (1989-09-01), Scharp et al.
patent: 4883666 (1989-11-01), Sabel et al.
patent: 4892538 (1990-01-01), Aebischer et al.
patent: 4902295 (1990-02-01), Walthall et al.
patent: 4942129 (1990-07-01), Goosen et al.
patent: 5002661 (1991-03-01), Chick et al.
patent: 5026365 (1991-06-01), Rossini et al.
patent: 5049493 (1991-09-01), Khosla et al.
patent: 5082670 (1992-01-01), Gage et al.
patent: 5084350 (1992-01-01), Chang et al.
patent: 5106627 (1992-04-01), Aebischer et al.
patent: 5122464 (1992-06-01), Wilson et al.
patent: 5167762 (1992-12-01), Carr et al.
Emerich et al Cell Transplantation, vol. 1, CT 126, 1992.
Kaliatsos et al Exp. Neurol 112:161, 1991.
Aebischer et al., Biomaterials, 12, 50-56 (1991).
Algire et al., J. National Cancer Institute, 15, 493-506 (1954).
Altman, Trans. Am. Soc. Artif. Intern. Organs, vol. XXX, 382-386 (1984).
Altman et al., Diabetes, 35, 625-633 (1986).
Archer et al., J. Surgical Research, 28, 77-85 (1980).
Backman et al., Psychol. Aging, 6, 489-492 (1991).
Baetge et al., PNAS, 85, 3648-3652 (1988).
Baetge et al., PNAS, 83, 5454-5458 (1986).
Bartus et al., Science, 217, 408-417 (1982).
Bartus, Treatment Development Strategies For Alzheimer's Disease, Mark Powley Associates (T. Crook, ed.), Ch. 2, 15-33.
Beal et al., J. Neurosci., 8, 3901-3908 (1988).
Beal, Synapse, 3, 38-47 (1989).
Besnard et al., J. Biol. Chem., 266, 18877-18883 (1991).
Bontempo et al., Blood, 69, 1721-1724 (1987).
Britt et al., Diabetes, 30, 580-583 (1981). Please note that the vol. and page Nos. for this document were incorrectly typed in the specification. This citation stands corrected above.
Burgess et al., Ann. Rev. Biochem, 58, 575-606 (1989).
Cabasso, I., Encyclopedia of Chemical Technology, 12, 492-517 (1980).
Cai et al., Artificial Organs, 12(5), 388-393 (1988).
Cepko, Neuron, 1, 345-353 (1988).
Chang et al., Human Gene Therapy, 4, 433-440 (1993).
Christenson, Ph.D. Thesis, Brown University (1990). Please note that the year of this thesis was incorrectly stated in the specification. This citation stands corrected above.
Christenson et al., J. Biomed. Mat. Res., 23, 705-718 (1989).
Cohen et al., J. Am. Chem. Soc., 112, 7832-7833 (1990).
Cole et al., Diabetologia, 35, 231-237 (1992).
Colton et al., The Kidney, W.B. Saunders Co. (B.M. Brenner and F.C. Rector, eds.), 2425-89 (1981).
Darquy et al., Trans. Am. Soc. Artif. Intern. Organs, vol. XXXIII, 356-358 (1987).
Darquy et al., Diabetologia, 28, 776-780 (1985).
Dionne et al., ASAIO Abstracts, 99 (1993).
Dionne, Ph.D. Thesis, Massachusetts Institute of Technology, 170-184 (1989).
Dupuy et al., J. Biomed. Mat. Res., 22, 1061-1070 (1988).
Edmunds et al., Applied Biochemistry and Biotechnology, vol. 20/21, 603-619 (1989).
Emerich et al., Neuromethods 21, Animal Models of Neurological Disease, 65-134 (1992).
Emerich et al., Cell Transplantation, vol. 1, 1-27 (1992).
Emerich et al., Neuroscience and Biobehavioral Reviews, 16, 437-447 (1992).
Faithfull, Anaesthesia, 42, 234-242 (1987).
Fan et al., Diabetes, 39, 519-522 (1990).
Folstein et al., J. Psychiat. Res., 12, 189-198 (1975).
Foster et al., Brain Res., 336, 207-214 (1985).
Frim et al., NeuroReport, vol. 4, 367-370 (1993).
Fu et al., Transplantation, 47, 432-435 (1989).
Gordon et al., Nature, 326, 403-405 (1987).
Gritz et al., Gene, vol. 25, 179-188 (1983).
Grulke, Polymer Handbook, 3rd Ed., John Wiley & Sons (J. Brandrup and E.H. Immergut, eds.), Ch. 7, pp. 519-520.
Herscovitch et al., J. Cereb. Blood Flow Metab. 7, 527-542 (1987).
Hoffman et al., Exp. Neurology, 122, 100-106 (1993).
Hoffman, Ph.D. Thesis, Univ. Rochester, Division of Biology and Medicine (1993).
Hoyle et al., Neuron, 10, 1019-1034 (1993).
Iwata et al., Diabetes, 38, 224-225 (1989); discloses islets microencapsulated in agarose gel.
Jarret et al., Lancet, (2), 1009-1012 (1976).
Jolley et al., Transplantation Proceedings, vol. IX, 363-365 (1977).
Kaneda, et al., Neuron, 6, 583-594 (1991).
Klomp, Journal of Biomedical Materials Research, 17, 865-871 (1983).
Koliatsos et al., Experimental Neurology, 112, 161-173 (1991).
Koliatsos et al., Annals of Neurology, 30, 831-840 (1991).
Kordower et al., J. Comp. Neurol, 298, 443-457 (1990).
Kromer, Science, 235, 214-216 (1986).
Lacy et al., Science, 204, 312-313 (1979).
Lacy et al., Science, 254, 1782-1784 (1991).
Land et al., Nature, 304, 596-602 (1983).
Lemke et al., Neuron, 1, 73-83, (1988).
Leung et al., Artificial Organs, 7, 208-212 (1983).
Lim et al., Science, 210, 908-910 (1980).
Liu et al., Human Gene Therapy, 4, 291-301 (1993).
Livett, Physiological Reviews, 64, 1103-1161 (1984).
Matthews et al., Recent Advances in Germfree Research, Tokai Univ. Press, 61-64 (1981).
Maysinger et al., Neurochem. Int., 23, No. 2, 123-129 (1993).
Mercer et al., Neuron, 7, 703-716 (1991).
Miniats et al., Can. J. Comp. Med., 42, 428-437 (1978).
Nakahira et al., J. Biol. Chem., 265, 19786-19791 (1990).
NASA Tech. Briefs NPO-17517, vol. 15, #1, Item # 113, pp. i, 1, 1a and 1b-29b (1991).
Nordberg et al., Neuroscience Lett., 72, 115-119 (1986).
O'Shea et al., Diabetes, 35, 943-946 (1986).
O'Shea et al., Biochimica et Biophysica Acta, 804, 133-136 (1984).
Olson et al., J. Neural Transmission, 4, 79-95 (1992).
Olson, Proceedings of the Xth Meeting of the World Society for Stereotactic and Functional Neurosurgery, pp. 250-267 (1990).
Palmiter et al., PNAS, 88, 478-482 (1991).
Piccardo et al., Neuro Report, 3, 353-356 (1992).
Rabizadeh et al., Science, 261, 345-348 (1993).
Ray et al., PNAS, 90, 3602-3606 (1993).
Reach, Biomed. Biochim. Acta., 43, 569-576 (1984).
Richards et al., PNAS, 89, 8591-8595 (1992).
Ricordi et al., Transplantation, 45(6), 1148-1151 (1988).
Roberts et al., Synapse, 3, 363-371 (1989).
Ronel et al., Journal of Biomedical Materials Research 17, 855-864 (1983).
Rosenberg et al., Science, 242, 1575-1578 (1988).
Sakimura et al., Gene, 60, 103-113, (1987).
Sanberg et al., Exp. Neurol., 66, 444-466 (1979).
Sanberg et al., Med. J. Aust., 1, 407-409 (1981).
Scharp et al., World J. Surg., 8, 221-229 (1984).
Schinstine et al., Molecular and Cellular Approaches for the Treatment of Neurological Disease, (S.G. Waxman, ed.), Raven Press, Ch. 16, 311-323 (1993).
Schwarcz et al., Neurosci. Lett., 38, 85-90 (1983).
Schwarcz et al., Science, 219, 316-318 (1983).
Schweitzer et al., J. Cell Biol., 101, 667-676 (1985).
Short et al., Dev. Neurosci., 12, 34-45 (1990).
Soeldner et al., Diabetes, 14, 771-779 (1965).
Soon-Shiong et al., Proc. Natl. Acad. Sci. USA, 90, 5843-5847 (1993).
Southern et al., J. Mol. Appl. Genet., 1, 327-
Baetge Edward E.
Emerich Dwaine F.
Gentile Frank T.
Hammang Joseph P.
Lindner Mark D.
Cytotherapeutics, Inc.
Elrifi Ivor R.
Hsi Petrina S.
Ziska Suzanne E.
LandOfFree
Compositions and methods for the delivery of biologically active does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for the delivery of biologically active, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for the delivery of biologically active will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1072861