Compositions and methods for the delivery of biologically active

Details Compositions and methods for the delivery of biologically active Compositions and methods for the delivery of biologically active

1995-05-25

1997-08-12

Ziska, Suzanne E.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4351723, 435347, 435382, 435373, 424 932, 424 9321, 424 933, 424 937, 424 931, C12N 1500, C12N 500, A01N 6300

Patent

active

056564813

ABSTRACT:
This invention provides improved devices and methods for long-term, stable expression of a biologically active molecule using a biocompatible capsule containing genetically engineered cells for the effective delivery of biologically active molecules to effect or enhance a biological function within a mammalian host. The novel capsules of this invention are biocompatible and are easily retrievable. This invention specifically provides improved methods and compositions which utilize cells transfected with recombinant DNA molecules comprising DNA sequences coding for biologically active molecules operatively linked to promoters that are not subject to down regulation in vivo upon implantation into a mammalian host. Furthermore, the methods of this invention allow for the long-term, stable and efficacious delivery of biologically active molecules from living cells to specific sites within a given mammal. In addition, this invention provides a general means for maintaining, for extended periods of time, the in vivo expression of transgenes.

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