Compositions and methods for stimulating gastrointestinal...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Details

C530S330000, C424S551000

Reexamination Certificate

active

07932231

ABSTRACT:
The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a peptidyl analog of ghrelin to said patient.

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patent: 2005/0148515 (2005-07-01), Dong et al.
patent: 2007/0191283 (2007-08-01), Polvino
patent: 2008/0261873 (2008-10-01), Geesaman
patent: WO 03/051389 (2003-06-01), None
patent: WO 2004/009616 (2004-01-01), None
patent: WO 2004/014415 (2004-02-01), None
Murray, 2005, Neurogastroenterology, 54, 1693-1698.
McDowell, 1995, PNAS, 92, 11165-11169.
Trudel, 2003, Peptides, 24, 531-534.
Kojima, M. and Kangawa, K., “Ghrelin: Structure and Function”, 2005, Physiol. Rev., 85:495-522.
Murray, C. D. R., et al, “Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study”, Gut, 2005, 54:1693-1698.
Masuda, Y. et al., “Ghrelin stimulates gastric acid secretion and motility in rats”, Biochem. Biophys Res. Comm., 2000, 276:905-908.
Peeters, T. L., “Central and peripheral mechanisms by which ghrelin regulates gut motility”, J. Physiol and Pharmacol., 2003, 54(Supp4):95-103.
Poitras, P. et al., “Gastrokinetic effect of ghrelin analog RC-1139 in the rat Effect on post-operative and on morphine induced ileus”, Peptides, 2005, 26:1598-1601.
Trudel, L. et al., “Two new peptides to improve post-operative gastric ileus in dog”, Peptides, 2003, 24:531-534.

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