Compositions and methods for sirna inhibition of angiogenesis

Details Compositions and methods for sirna inhibition of angiogenesis Compositions and methods for sirna inhibition of angiogenesis

2006-12-12

2006-12-12

McGarry, Sean (Department: 1635)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024100, C536S024300, C536S024330

Reexamination Certificate

active

07148342

ABSTRACT:
RNA interference using small interfering RNAs which are specific for the vascular endothelial growth factor (VEGF) gene and the VEGF receptor genes Flt-1 and Flk-1/KDR inhibit expression of these genes. Diseases which involve angiogenesis stimulated by overexpression of VEGF, such as diabetic retinopathy, age related macular degeneration and many types of cancer, can be treated by administering the small interfering RNAs.

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