Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Reexamination Certificate
2006-03-28
2006-03-28
Prouty, Rebecca (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
C435S119000, C435S197000
Reexamination Certificate
active
07018631
ABSTRACT:
Polynucleotides encoding a carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a chemotherapeutic prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing tumor cells to a prodrug chemotherapeutic agent and inhibiting tumor growth with this enzyme are also provided. In addition, screening assay for identification of drugs activated by this enzyme are described.
REFERENCES:
patent: 6107549 (2000-08-01), Feng et al.
patent: WO 93/01281 (1993-01-01), None
Alexson S.E. H. et al., “Molecular Cloning and Identification of a Rat Serum Carboxylesterase Expressed in the Liver”,J. Biol. Chem.1994; 260:25 17118-17124.
Danks M.K., et al., “Overexpression of a Rabbit Liver Carboxylesterase Sensitizes Human Tumor Cells to CPT-11”,Cancer Research1998; 58:20-22.
Miller S.K., et al., “Purification and Physical Properties of Oligomeric and Monomeric Carboxylesterases from rabbit Liver”,J. Biol. Chem.1980; 255:15 7161-.
Potter et al., Isolation and Partial Characterization of a cDNA Encoding a Rabbit Liver Carboxylesterase That Activates the Prodrug Irinotecan (CPT-11),Cancer Research, 1998; 58:2646-2651.
Potter et al., “Isolation and Characterization of a cDNA Encoding a Rabbit Carbosylesterase That Converts CPT-11 to SN-38”,Proc. Amer. Assoc. Canc. Res., 1998; 39:421.
Potter et al., “Cellular Localization Domains of a Rabbit and a Human Carboxylesterase: Influence on Irinotecan (CPT-11) Metabolism by the Rabbit Enzyme”,Cancer Research, 1998; 58: 3627-3632.
Senter et al., “The Role of Rat Serum Carboxylesterase in the Activation of Paclitaxel and Camptothecin Prodrugs”,Cancer Research, 1996; 56:1471-1474.
Sigma Chemical Company Catalog, Product No. E2884 and E9636.
Cashman et al., “Pharmcokinetics and Molecular Detoxication”, Environmental Health Perspectives 1996 104:23-40.
Niculescu-Duvaz et al., “Antibody-directed enzyme prodrug therapy (ADEPT) :a review”, Advanced Drug Delivery Reviews 1997 151-172.
Niculescu-Duvaz et al., “Gene-Directed Enzyme Prodrug Therapy”, Bioconjugate Chem. 1998 9:4-22.
Guichard et al., “Conversion of the CPT-11 Metabolite APC to SN-38 by Rabbit Liver Carboxylesterase1”. Clinical Cancer Research 1998 4:3089-3094.
Huang et al., “Structure-Activity Relationships for Substrates and Inhibitors of Mammalian Liver Microsomal Carboxylesterase”, Pharmaceutical Research 1996 13(10):1495-1500.
Kroetz et al., “Glycosylation-Dependent Activity of Baculovirus-Expressed Human Liver and carboxylesterases:cDNA Cloning and Characterization of Two Highly Similar Enzyme Forms”, Biochemistry 1993 32:11606-11617.
Meck et al., “A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-111”, Cancer Research 2001 61:5083-5089.
Ozols J., “Isolation, Properties, and the Complete Amino Acid Sequence of a Second Form of 60-kDa Glycoprotein Esterase”, J. Biol. Chem. 1989 264 (21):12533-12545.
Pawlik et al., “Use of the Ornithine Decarboxylase Promotor to Achieve N-MYC-Mediated Overexpression of a Rabbit Carboxylesterase to Sensitize Neuroblastoma Cells to CPT-11”, Molecular Therapy 2000 1(5):457-463.
Riddles et al., “Cloning and analysis of a cDNA encoding a human liver carboxylesterase”, Gene 1991 108:289-292.
Satoh et al., “The Mammalian carboxylesterases:From Molecules to Functions”, Annu. Rev. Pharmacol. Toxicol. 1998 38:257-288.
Tsuji et al., “CPT-11 Converting Enzyme from Rat Serum:Purification and Some Properties”, J. Pharmacobio-Dyn. 1991 14:341-349.
Wadkins et al., “Structural constraints Affect the Metabolism of 7-Ethyl-10-[4-(1-piperdino)-1-piperidino] carbonyloxycamptothecin (CPT-11) by Carboxylesterases”, Mol. Pharmacol. 2001 60(2):355-362.
Satoh et al., “Metabolic Activation of CPT-11, 7-Ethyl-10-[4-(1-piperidino)-1-pierperidino] carbonyloxycamptothecin, a Novel Antitumor Agent, by Carboxylesterase”, Biol. Pharm. Bull. 1994 17(5):662-664.
Danks Mary K.
Houghton Peter J.
Potter Philip M.
Licata & Tyrrell P.C.
Prouty Rebecca
St. Jude Children's Research Hospital
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