Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1996-05-21
1999-09-07
Jacobson, Dian C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530810, 530811, 530814, 530817, 530825, 930200, 930280, C07K 14195, C07K 14245, C07K 1702, C07K 1714
Patent
active
059488891
ABSTRACT:
A method for screening compounds for antimicrobial activity is described that utilizes bacterial protein-protein binding in vitro. The method may be performed using immobilized elements and the immobilization may be carried out using a variety of immobilization means (e.g., columns, beads, adsorbents, nitrocellulose paper, etc.) in order to screen large libraries of compounds.
REFERENCES:
patent: 4016043 (1977-04-01), Schuurs et al.
patent: 4018653 (1977-04-01), Mennen
patent: 4424279 (1984-01-01), Bohn et al.
patent: 4568649 (1986-02-01), Bertoglio-Matte
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 5310663 (1994-05-01), Dobeli et al.
Appleton-Century-Crofts, Norwalk, CT, (1984), p. 193.
Jawetz, Melnick & Adelberg's Medical Microbiology, 19th ed, Appleton & Lange, Norwalk, CT (1991), p. 150.
J.F. Sessegolo et al., "Distribution of Serotypes and Antimicrobial Resistance of Streptococcus pneumoniae Strains Isolated in Brazil From 1988 to 1992", J. Clin. Microbiol., 32:906-911 (1994).
Anderson and Young, Quantitative Filter Hybridization in Nucleic Acid Hybridization (1985) pp. 73-111.
G.F. Brooks et al., Jawetz, Melnick & Adelberg's Medical Mirobiology, 19th ed, Appleton & Lange, Norwalk, CT (1991), p. 155.
Douillard and Hoffman, Basic Facts about Hybridomas, in Compendium of Immunology, vol. II, ed. by Schwartz (1981).
Kohler and Milstein, Nature 256:495-499 (1975).
European Journal of Immunology 6:511-519 (1976).
Reading, Journal of Immunological Methods 53:261-291 (1982).
Sambrook et al., Molecular Cloning, A Laboratory Manual, 2nd Ed., (Cold Spring Harbor Press, NY (1989).
M.A. Blanar and W.J. Rutter, "Interaction Cloning: Identification of a helix-loop-helix Zipper Protein that Interacts with cFos," Science 256:1014 (1992).
P.A.J. de Boer et al., "Isolation and Properties of minB, a Complex Genetic Locus Involved in Correct Placement of the Division Site in Escherichia coli " Journal of Bacteriology, 170:2106 (1988).
Ausubel et al., Current Protocols in Molecular Biology (John Wiley & Sons) (pp. 13.14.1-13.14.14) (1994).
A Higashitani et al., "A Cell Division SulA of Escherichia coli Directly Interacts with FTSZ Through GTP Hydrolysis," Biochemical and Biophysical Research Communications, 209: 198-204 (1995).
W. Margolin et al., "Cloning and Characterization of a Rhizobium meliloti Homolog of the Escherichia coli Cell Division Gene ftsZ," Journal of Bacteriology 173(18): 5822-5830 (1991).
A. Nishimura, "The new gene controlling the frequency of cell division per round of DNA replication in Escherichia coli," Molecular and General Genetics 215:286-293 (1989).
B. Beall et al., "Cloning and characterization of bacillus subtilis homologs of Escherichia coli cell division genes ftsZ and ftsA," Journal of Bacteriology 170: 4855-4864 (1988).
J. Ward et al., "A lac-ftsZ gene fusion is an analog of cell division inhibitor sulA," Journal of Bacteriology 157:815-820 (1984).
E. Bi et al., "Cell division Inibitors SulA and MinCD prevent formation of the FtsZ ring," Journal of Bacteriology 175:1118-1125 (1993).
E. Harry et al., "Cloning and expression of a Bacillus subtilis division initiation gene for which a homolog has not been identified in another organism," Journal of Bacteriology 171:6835-6839 (1989).
W. Margolin et al., "Rhizobium meliloti contains a novel second homolog of the cell division gene ftsZ," Journal of Bacteriology 176:2033-2043 (1994).
K. Cam et al., "Sigma S-dependent overexpression of ftsZ in Escherichia coli K-12 rpoB mutant that is resistant to the division inhibitors DicB and DicF RNA," Molecular and General Genetics 248:190-194 (1995).
I. Ruberti et al., "A class of gyrB mutants, substantially unaffected in DNA topology, suppressed the Escherichia coli K12 ftsZ.sub.84 mutation," Molecular Microbiology 5(5): 1065-1072 (1991).
D. Vinella et al., "Penicillin-Binding Protein 2 Inactivation in Escherichia coli Results in Cell Division Inhibition, Which is Relieved by FtsZ Overexpression," Journal of Bacteriology 175:6704-6710 (1993).
Y. Ishino et al., "Nucleotide sequence of the lig gene and primary structure of DNA ligase of Escherichia coli," Molecular and General Genetics 204:1-7 (1986).
C. Byrne et al., "DNA sequences of the cysK regions of Salmonella typhimurium and Escherichia coli and linkage of the cysK regions to ptsH," Journal of Bacteriology 170: 3150-3157 (1988).
R. Fleisschmann et al., "Whole-genome random sequencing and assembly of Haemophilus influenzae Rd," Science 269:496-512 (1995).
P.R. Murray et al., "Antimicorbial Susceptibility Testing: General Considerations," Manual of Clinial Microbiology, ASM Press, Washington, D.C., pp. 1277-1280 (1995).
Morch, M.-D. Nucleic Acids Research 16:6157-6172 (1988).
Meador, J. III et al. Gene 95:1-7 (1990).
Chang-Yeh, A. et al. Nucleic Acids Research 19(13):3667-3672 (1991).
de Boer Piet A. J.
Hale Cynthia A.
Case Western Reserve University
Jacobson Dian C.
LandOfFree
Compositions and methods for screening antimicrobials does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for screening antimicrobials, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for screening antimicrobials will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1805382