Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Reexamination Certificate
2007-12-18
2007-12-18
Monshipouri, Maryam (Department: 1656)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
C514S012200, C435S194000
Reexamination Certificate
active
10875100
ABSTRACT:
The present invention pertains to compositions and methods used to ascertain if putative antibiotics trigger a cell envelope stress response in bacterial organisms. In one aspect of the invention, three two-component systems are described: LiaR & LiaS (formerly YvqCE); YvcP & YvcQ; and BceR & BceS (formerly YtsAB). These systems, for example, can be used to analyze antibiotics such as vancomycin, bacitracin, nisin, and ramoplanin, which interfere with the lipid II cycle in the cytoplasmic membrane.
REFERENCES:
Cao & Helmann et al., J. Bactereiology, 184(22), 6123-6129, 2002.
Helmann John D.
Mascher Thorsten
Burns & Levinson LLP
Cornell Research Foundation Inc.
Erlich, Esq. Jacob N.
Monshipouri Maryam
Susan Janine M.
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