Compositions and methods for repair of cartilage and bone

Details Compositions and methods for repair of cartilage and bone Compositions and methods for repair of cartilage and bone

1988-12-05

1990-02-27

Cannon, Alan W.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Implantable prosthesis

Bone

623 11, 623 66, 424 95, 530838, 530840, 514 2, A61F 228, A61K 3512

Patent

active

049042599

ABSTRACT:
A defect is provided in cartilage or bone, or both, to excise damaged or pathological tissue, and it is filled with an implant having capability for complete regeneration of the skeletal tissue as a chondrogenic or osteogenic phenotype. The implant comprises cells expressing a chondrocyte phenotype (80.times.10.sup.6 cells/ml) embedded in a biocompatible matrix having about 20% serum, which provides a permissive environment for maturation and transformation of the implant to a fully integrated state with the surrounding tissue. A portion of the implant may comprise a bone segment or a bone substitute.

REFERENCES:
patent: 4846835 (1989-07-01), Grande

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