Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heavy metal containing doai
Patent
1993-10-06
1997-05-20
Burn, Brian M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heavy metal containing doai
514492, 514645, 514740, A61K 3128
Patent
active
056312849
ABSTRACT:
Compositions and methods for relaxing smooth muscle in a warm-blooded animal are provided, comprising the step of administering to the animal a transition-metal nitrosyl complex. In one aspect, the transition-metal nitrosyl complex is represented by the formula L.sub.3 M(NO).sub.y X.sub.3-y where L is a two-electron Lewis base or L.sub.3 is a six-electron Lewis base, M is a Group 6 or 8 transition-metal, and when y is 1, X is carbon monoxide, and when y is 2, X is a halide or pseudohalide. In another aspect, the transition-metal nitrosyl complex is represented by the formula [M(NO).sub.2 X.sub.y ].sub.2 where X is a halide or pseudohalide, and when M is a Group 6 transition-metal, y is 2, and when M is a Group 8 transition-metal, y is 1. Methods are also described for treating hypertension, angina pectoris, congestive heart disease, and impotence utilizing pharmaceutical compositions comprising the above-described transition-metal nitrosyl complexes.
REFERENCES:
patent: 4571391 (1986-02-01), Riley et al.
patent: 4748160 (1988-05-01), Bennion et al.
Butler, Anthony R. and Williams, D. Lyn H., "The Physiological Role of Nitric Oxide," Chem. Soc. Rev. 22(4):233-41, 1993.
Clarke, M. J. and Gaul, J. B., "Chemistry Relevant to the Biological Effects of Nitric Oxide and Metallonitrosyls," Struct. Bonding (Berlin) 81:147-81, 1993.
Legzdins Peter
Pang Catherine C. Y.
Shaw Michael J.
Burn Brian M.
University of British Columbia
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