Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues
Reexamination Certificate
2005-06-07
2005-06-07
Riley, Jezia (Department: 1637)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
C530S350000, C536S022100, C435S006120
Reexamination Certificate
active
06903183
ABSTRACT:
Compositions and methods relating to the regulation of transport of cholesterol into the mitochondria of a cell and, therefore, for the regulation of steroidogenesis are provided. Compositions include nucleic acid molecules encoding a steroidogenic acute regulatory protein (StAR), StAR protein molecules and peptides having amino acid sequences as disclosed herein, and anti-StAR antibodies. Methods include immunoassays using anti-StAR antibodies and nucleic acid based screening methods for pathologies correlated with defects in StAR, such as lipoid congenital adrenal hyperplasia and dose sensitive sex reversal. In addition, these compositions and methods may be useful for treatment of steroid hormone-dependent disorders, in particular, for lipoid congenital adrenal hyperplasia.
REFERENCES:
patent: 5807678 (1998-09-01), Miller et al.
Clark, Barbara J. and Stocco, Douglas M., “Expression of a Novel LH-Induced Protein Responsible for the Acute Regulation of Steroidogenesis in Mouse Leydig Tumor Cells”, Dallas IX International Congress on Hormonal Steroids, Sep. 24-29, 1994, Hyatt Regency at Reunion, Dallas, Texas, C185.
Clark, et al., “Expression of the Steroidogenic Acute Regulatory (StAR) Protein: A Novel LH-Induced Mitochondrial Protein Required for the Acute Regulation of Steroidogenesis in Mouse Leydig Tumor Cells”,Endocrine Research,21(1&2), 243-257 (1995).
Clark, et al., “Hormonal and Developmental Regulation of the Steroidogenic Acute Regulatory Protein”,Molecular Endocrinology,vol. 9, No. 10, 1346-1355 (1995).
Clark, et al., “The Purification, Cloning, and Expression of a Novel Luteinizing Hormone-induced Mitochondrial Protein in MA-10 Mouse Leydig Tumor Cells”,The Journal of Biological Chemistry,vol. 269, No. 45, Nov. 11, 1994, pp. 28314-28322.
Conference on the Adrenal Cortex, 1994.
Guo, et al., “Diagnosis of X-Linked Adrenal Hypoplasia Congenita by Mutation Analysis of the DAX1 Gene,”JAMA,274(4):324-330, Jul. 1995.
Hartung, et al., “Molecular Cloning and In Vivo Expression of the Bovine Steroidogenic Acute Regulatory Protein,”Biochemical and Biophysical Research Communications,215(2) :646-653, Oct. 1995.
Huang, et al., “Corticotropin-Releasing Hormone (CRH) Stimulates Steroidogenesis in Mouse Leydig Cells”, Society for the Study of Reproduction, Biology of Reproduction/vol. 50/Supplement 1, Jul. 24-27, 1994, 27th Annual Meeting, University of Michigan, Ann Arbor, Michigan.
Keyes, et al., “Steroidogenic Acute Regulatory Protein (StAR) in the Rabbit Corpus Luteum: Dependence Upon the Luteotrophic Hormone, 17B-Estradiol”, Society for the Study of Reproduction, Biology of Reproduction/vol. 52/Supplement 1, 39, Jul. 9-12, 1995, 28th Annual Meeting, University of Michigan, Ann Arbor, Michigan.
King, et al., “Steroid Production after in Vitro Transcription, Translation, and Mitochondrial Processing of Protein Products of Complementary Deoxyribonucleic Acid for Steroidogenic Acute Regulatory Protein”,Endocrinology,vol. 136, No. 11, 5165-5176 (1995).
Lin, D., et al., “Mutations in Steroidogenic Acute Regulatory Protein (StAR) Cause Congenital Lipoid Adrenal Hyperplasia (Lipoid CAH): Genetic Evidence for an Indispensible Role for StAR in Adrenal and Gonadal Steroidogenesis”, Program & Abstracts, P3-620, 77th Annual Meeting, Jun. 14-17, 1995, Washington, D.C.
Lin, et al., “Role of Steroidogenic Acute Regulatory Protein in Adrenal and Gonadal Steroidogenesis”,Science,vol. 267, pp. 1828-1831, Mar. 24, 1995.
Lipid Metabolism 1995, Kimball Union Academy, Meriden, NH, Jun. 25-30.
Muscatelll, et al., “Mutations in the DAX-1 Gene Give Rise To Both X-Linked Adrenal Hypoplasia Congenita and Hypogonadotropic Hypogonadism,”Nature,372:672-676, Dec. 1994.
Ronen-Fuhrmann, et al., “Steroidogenic Acute Regulatory Protein (StAR) : Immunocytochemical Characterization of a Novel Hormone-Induced Protein Required for the Acute Regulation of Steroidogenesis”, Israel Endocrine Society, 1995.
Stocco, et al., “Role of the Steroidogenic Acute Regulatory Proten (StAR) in Steroidogenesis,”Biochemical Pharmacology,51:197-205, 1996.
Stocco, et al., “Regulation of the Acute Production of Steroids in Steroidogenic Cells,”Endocrine Reviews,17(3) :1-24, Jun. 1996.
Stocco, et al., “Characterization of the Protein Responsible for the Acute Regulation of Steroidogenesis in Mouse Leydig Tumor Cells”, XIIIthTestis Workshop: Cellular and Molecular Regulation of Testicular Cells, Final Program and Abstract Book, Mar. 30-Apr. 1, 1995, Raleigh North Carolina, Serono Symposia USA.
Sugawara, et al., “Human steroidogenic acute regulatory protein: Functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogen to chromosome 13”,Proc. Natl. Acad. Sci., U.S.A.,vol. 92, pp. 4778-4782, May 1995.
Sugawara, et al., “Structure of the Human steroidogenic Acute Regulatory Protein (StAR) Gene: StAR Stimulates Mitochondrial Cholesterol 27-Hydroxylase Activity”,Biochemistry(1995), 34:12506-12512.
Swain, et al., “Mouse DAX1 Expression is Consistent With a Role in Sex Determination as Well as in Adrenal and Hypothalamus Function,”Nature Genetics,12:404-409, Apr. 1996.
Yanase, et al., “New Mutations of DAX-1 Genes in Two Japanese Patients with X-Linked Congenital Adrenal Hypoplasia and Hypogonadotropic Hypogonadism,”Journal of Clinical Endrocrinology and Metabolism,81(2) :530-535, 1996.
Zanaria, et al., “An Unusual Member of the Nuclear Hormone Receptor Superfamily Responsible for X-Linked Adrenal Hypoplasia Congenita,”Nature,372:635-641, Dec. 1994.
Arensburg, et al., “Decidual and Giant Trophoblast Cell Expression of Steroidogenic Enzymes During Early Pregnancy in Mice,” Second International Meeting on Molecular Steroidogenesis, 1996.
Balasubramanian, et al., “Regulation of Porcine Granulosa Cell Steroidogenic Acute Regulatory Protein (StAR) by Insulin-Like Growth Factor I: Synergism with Follicle-Stimulating Hormone or Protein Kinase A Agonist,”Endocrinology,138(1) :433-439, 1997.
Bose, et al., “The Pathophysiology and Genetics of Congenital Lipoid Adrenal Hyperplasia,”New England Journal of Medicine,335:1870-1878, Dec. 1996.
Choi, et al., “Diethylumbelliferyl Phosphate Inhibits Steroidogenesis by Interfering with a Long-Lived Factor Acting Between Protein Kinase A Activation and Induction of the Steroidogenic Acute Regulatory Protein (StAR),”Eur. J. Biochem.,234:680-685, 1995.
Clark, B.J. & Stocco, D.M., “StAR-A Tissue Specific Acute Mediator of Steroidogenesis,”TEM,7(7) :227-233, 1996.
Pescador, et al., “Steroidogenic Acute Regulatory Protein in Bovine Corpora Lutea,”Biology of Reproduction,55:485-491, 1996.
Price, et al., “Evidence for Oestradiol Regulation of Steroidogenic Acute Regulatory Protein mRNA in Ram Testis,” Society for the Study of Fertility, Nottingham, U.K., Jul. 15-17, 1996, to be published in theJournal of Reproduction&Fertility Abstract Series,1996.
Rodgers, et al., “Concentrations of Steroid Acute Regulatory Protein, P450 Cholesterol Side-Chain Cleavage Enzyme and 3β-Hydroxysteroid Dehydrogenase During Prostaglandin F2α-Induced Luteal Regression in Cattle,” Australian Society of Reproduction, Melbourne, Australia.
Stocco, et al., “Differential Effects of Dimethylsulfoxide on Steroidogenesis in Mouse MA-10 and Rat R2C Leydig Tumor Cells,”Endocrinology,136(7) :2993-2999, 1995.
Stocco, D.M. & Clark, B.J., “Corticotropin-Dependent Synthesis of Mitochondrial Proteins Involved in the Acute Regulation of Steroidogenesis,”Endocrinology and Diabetes,3:195-201, 1996.
Townson, et al., “Expression of the Steroidogenic Acute Regulatory Protein in the Corpus Luteum o the Rabbit: Dependence Upon the Lut
Clark Barbara J.
Stocco Douglas M.
Cox & Smith Incorporated
Riley Jezia
Texas Tech University Health Services Center
LandOfFree
Compositions and methods for regulation of steroidogenesis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for regulation of steroidogenesis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for regulation of steroidogenesis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3476560