Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-11-04
1999-02-16
Marschel, Ardin H.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 536 231, 536 235, C07H 2100, C12Q 168
Patent
active
058722300
ABSTRACT:
Compositions and methods relating to the regulation of transport of cholesterol into the mitochondria of a cell and, therefore, for the regulation of steroidogenesis are provided. Compositions include nucleic acid molecules encoding a steroidogenic acute regulatory protein (StAR), StAR protein molecules and peptides having amino acid sequences as disclosed herein, and anti-StAR antibodies. Methods include immunoassays using anti-StAR antibodies and nucleic acid based screening methods for pathologies correlated with defects in StAR, such as lipoid congenital adrenal hyperplasia. In addition, these compositions and methods may be useful for treatment of steroid hormone-dependent disorders, in particular, for lipoid congenital adrenal hyperplasia.
REFERENCES:
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Clark Barbara J.
Stocco Douglas M.
Marschel Ardin H.
Mayfield Denise
Riley Jezia
Texas Tech University Health Sciences Center
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