Compositions and methods for regulating receptor clustering

Details Compositions and methods for regulating receptor clustering Compositions and methods for regulating receptor clustering

2008-07-08

2008-07-08

Rao, Manjunath (Department: 1647)

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Structurally-modified antibody, immunoglobulin, or fragment...

C435S007200, C435S375000, C530S395000

Reexamination Certificate

active

07396529

ABSTRACT:
The invention relates to isolated complexes comprising one or more galectin associated with Mgat5 modified glycan or polylactosamine modified glycan, and isolated lectin-Mgt5 modified glycan lattice comprising an array of multivalent interactions among lectins, Mgat5 modified glycans, polylactosamine modified glycans, and/or glycoproteins. Methods for evaluating a test compound for its ability to regulate receptor clustering through glycans on cell surfaces; and methods for regulating receptor clustering on cell surfaces comprising altering glycans on the cell surface associated with receptor clustering are also discovered.

REFERENCES:
patent: WO 99/12041 (1999-03-01), None
Demetriou et al., Nature Feb. 8, 2001 409(6821):733-9.
Rabinovitch et al., Immunology 1999 97:100-106.
Granovsky et al., Nature Medicine, Mar. 2000, 6(3):306-312.
Dennis et al., Biochemica et Biophysica Acta. 1999;1473:21-31.
Ki-Young Do, et al., J Biol Chem. Sep. 23, 1994;269(38):23456-23464.
Palcic et al., J Biol Chem. Apr. 25, 1990;265(12):6759-6769.
Cummings et al., J Biol Chem. Nov. 25, 1982; 257(22):13421-13427.
Lemaire et al., J Biol Chem. Mar. 18, 1994;269(11):8069-8074.
Essentials of Glycobiology. Varki et al., Eds. Cold Spring Harbor Laboratory Press. 1999. New York. pp. 2-3, and 538-540.
Andersen et al., Curr Opin Biotech 1994 5:546-549.
Goochee et al., Biotechnology, Dec. 9, 1991:1347-1355.
Barkai et al., 1997,Nature387: 913-917, “Robustness in simple biochemical networks”.
Barondes et al., 1994,Cell76: 597-598, “Galectins: A Family of Animal β-Galactoside-Binding Lectins”.
Chung et al., 2000,The Journal of Immunology165: 3722-3729, “Galectin-1 Induces Partial TCR ζ-Chain Phosphorylation and Antagonizes Processive TCR Signal Transduction”.
Cummings et al., 1984,The Journal of Biological Chemistry259: 6253-6260, “The Distribution of Repeating [Galβ1 ,4GlcNAcβ1 ,3] Sequences in Asparagine-linked Oligosaccharides of the Mouse Lymphoma Cell Lines BW5147 and PHAR2.1”.
Cummings et al., 1982,The Journal of Biological Chemistry257: 13421-13427, “A Mouse Lymphome Cell Line Resistant to the Leukoagglutinating Lectin fromPhaseolus vulgarisIs Deficient In UDP-G1cNAc: α-D-mannoside β1,6 N-Acetylglucosaminyltransferase”.
Downward et al., 1990,Nature346: 719-723, “Stimulation of p21rasupon T-cell activation”.
Ellies et al., 1998,Immunity9: 881-890, “Core 2 Oligosaccharide Biosynthesis Distinguishes between Selectin Ligands Essential for Leukocyte Homing and Inflammation”.
Granovsky et al., 2000,Nature Medicine6: 306-312, “Suppression of tumor growth and metastasis in Mgat5-deficient mice”.
Gu et al., 1993,J. Biochem113: 614-619, “Purification and Characterization of UDP-N-Acetylglucosamine: α-6-D-Mannoside β1-6N-Acetylglucosaminyltranferase (N-Acetylglucosaminyltransferase V) from a Human Lung Cancer Cell Line”.
Hadari et al., 1995,The Journal of Biological Chemistry270: 3447-3453, “Galectin-8”.
Hubbard et al., 1986,Proc. Natl. Acad. Sci. 83: 1852-1856, “Glycosylation of the T-Cell Antigen-Specific Receptor And Its Potential Role In Lectin-Mediated Cytotoxicity”.
Karsan et al., 1998,J. Clin. Invest. 101: 2438-2445, “Leukocyte Adhesion Deficiency Type II Is A Generalized Defect of De Novo GDP-Fucose Biosynthesis”.
Knibbs et al., 1993,The Journal of Biological Chemistry1993: 14940-14947, “Carbohydrate-binding Protein 35”.
Lafaille et al., 1994,Cell78: 399-408, “High Incidence of Spontaneous Autoimmune Encephalomyelitis in Immunodeficient Anti-Myelin Basic Protein T Cell Receptor Transgenic Mice”.
Moloney et al., 2000,Nature406: 369-375, “Fringe is a glycosyltransferase that modifies Notch”.
Monks et al., 1998,Nature395: 82-86, “Three-dimensional segregation of supramolecular activation clusters in T cells”.
Offner et al., 1990,Journal of Neuroimmunology28: 177-184, “Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitis”.
Oliveira-dos-Santos et al., 1999,The Journal of Immunology162: 4490-4495, “CD28 Costimulation Is Crucial for the Development of Spontaneous Autoimmune Encephalomyelitis”.
Pace et al., 1999,The Journal of Immunology163: 3801-3811, “Restricted Receptor Segregation into Membrane Microdomains Occurs on Human T Cells During Apoptosis Induced by Galectin-1”.
Palcic et al., 1990,The Journal of Biological Chemistry265: 6759-6769, “Regulation of N-Acetylglucosaminyltransferase V Activity”.
Paulson et al., 1989,The Journal of Biological Chemistry264: 17615-17618, “Glycosyltransferases”.
Perillo et al., 1995,Nature378: 736-739, “Apoptosis of T Cells Mediated by Galectin-1”.
Priatel et al., 2000,Immunity12: 273-283, “The ST3Gal-l Sialytransferase Controls CD8+T Lymphocyte Homeostasis by Modulating O-Glycan Biosynthesis”.
Reich et al., 1997,Nature387: 617-620, “Ligand-specific oligomerization of T-cell receptor molecules”.
Reif et al., 1998,Immunity8: 395-401, “Networking Rho Family GTPases in Lymphocytes”.
Rudd et al., 1999,J. Mol. Biol. 293: 351-366, “Roles for Glycosylation of Cell Surface Receptors Involved in Cellular Immune Recognition”.
Saito et al., 1994,Biochemical and Biophysical Research Communications 198: 318-327, “cDNA cloning and chromosomal mapping of human N-acetylglucosaminyltransferase V+”.
Sato et al., 1992,The Journal of Biological Chemistry267: 6983-6990, “Binding Specificity of a Baby Hamster Kidney Lectin for H Type I and II Chains, Polylactosamine Glycans, and Appropriately Glycosylated Forms of Laminin and Fibronectin”.
Schachter et al.,Biochem. Cell Biol. 64: 163-181 , “Biosynthetic controls that determine the branching and microheterogeneity of protein-bound oligosaccharides”.
Shoreibah et al., 1993,The Journal of Biological Chemistry268: 15381-15385, “Isolation, Characterization, and Expression of a cDNA Encoding N-Acetylglucosaminyltransferase V”.
Trevillyan et al., 1990,The Journal of Immunology145: 3223-3230, “Differential Inhibition of T Cell Receptor Signal Transduction and Early Activation Events by a Selective Inhibitor of Protein-Tyrosine Kinase”.
Valltutti et al., 1995,Nature375: 148-151, “Serial triggering of many T-cell receptors by a few peptide-MHC complexes”.
Vespa et al., 1999,The Journal of Immunology162: 799-806, “Galectin-1 Specifically Modulates TCR Signals to Enhance TCR Apoptosis but Inhibit IL-2 Production and Proliferation”.
Viola et al., 1999,Science283: 680, “T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains”.
Viola et al., 1996,Science273: 104-106, “T Cell Activation Determined by T Cell Receptor Number and Tunable Thresdholds”.
Wall et al., 1988,Proc. Natl. Acad. Sci. USA85: 5644-5648, “Inhibitors of glycoprotein processing alter T-cell proliferative responses to antigen and to interleukin 2”.
Wang et al., 1998,The EMBO Journal17: 10-26, “Atomic structure of an αβ T cell receptor (TCR) heterodimer in complex with an anti-TCR Fab fragment derived form a mitogenic antibody”.
Wulfing et al., 1998,Science282: 2266, “A Receptor/Cytoskeletal Movement Triggered by Costimulation During T Cell Activation”.
Demetriou Michael et al.: “Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation.” Nature (London) vol. 409, No. 6821, 2001, pp. 733-739.
Granovsky Maria et al: “Mgat5 N-glycans regulate integrin and T cell receptor functions affecting cancer development and immune responses in vivo.” Glycoconjugate Journal, vol. 17, No. 1-2, Jan. 2000 p. 26 XP009005350 Second International Glycosyltransferase Symposium; Toro

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