Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2011-05-24
2011-05-24
Marvich, Maria (Department: 1633)
Chemistry: molecular biology and microbiology
Vector, per se
C435S069100, C435S091400, C536S023100, C536S023700, C536S024100
Reexamination Certificate
active
07947493
ABSTRACT:
The invention relates to compositions, specifically novel nucleic acid constructs encoding a cardiovirus 2A polypeptide operably linked to suitable promoters. Also, disclosed are methods whereby the nucleic acid constructs are introduced into cells or cell free systems to regulate cellular mRNA transcription and cap-dependent or internal ribosomal entry site (IRES)-dependent mRNA translation.
REFERENCES:
patent: 6440718 (2002-08-01), Probst
Lee and Pack, Utilization ofEscherichia coliTac Promoter inBacillus subtilis,Biotechnology Letters vol. 12 No. 12 925-930 (1990).
Roos et al, Polyprotein Processing of Theiler's Murine Encephalomyelitis Virus; Journal of Virology, Dec. 1989, vol. 63, (12) p. 5344-5353.
Pevear et al, Analysis of the Complete Nucleotide Sequence of the Picornavirus Theiler's Murine Encephalomyeltitis Virus Indicates That it is closely related to Cardioviruses, J Virology, 1987, vol. 61 (5), pp. 1507-1516.
Yarovoi et al, Human cell lines expressing hormone regulated T7 RNA polymerase localized at distinct intranuclear sites, Gene 275 (2001) 73-81.
Aminev, A.G., “Cardiovirus 2A protein induces the synthesis of modified . . . ,” Meeting talk and poster for Am Society for Virology Annual Meeting Jul. 21, 2001, Madison, WI.
Aminev, A.G., “Cardiovirus 2, 3CD and 3BCD localize to nuclei and induce . . . ,” Meeting talk and poster for Europic Picornavirus Meeting May 17, 2002, Cape Cod, MA.
Aminev, A.G., “Cardiovirus and Rhinovirus 2A, 3CD and 3BCD localize to nuclei . . . ,” Meeting poster for XIIth International Congress of Virology, Jul. 27, 2002, Paris, France.
Aminev, A.G., et al., “Encephalomyocarditis viral protein 2A localizes to nucleoli and inhibits cap-dependent mRNA translation,” Virus Research (2003) 95:45-57.
Aminev, A.G., et al., “Encephalomyocarditis viral (EMCV) proteins 2A and 3BCD localize to nucleoli and inhibit cellular mRNA . . . ,” Virus Research (2003) 95:59-73.
Binder, J.J., et al., “Genetic stability of attenuated mengovirus vectors with duplicate primary cleavage sequences,” (2003) Virology 312:481-494.
Duque, H., et al., “Phenotypic characterization of three phylogenetically conserved stem-loop motifs in the mengovirus 3′ untranslated region,” J. Virol. (2001) 75:3111-3120.
Hahn, H., et al., “Deletion mapping of the encephalomyocarditis virus primary cleavage site,” J. Virol. (2001) 75:7215-7218.
Hall, D.J., et al., “Cleavage site mutations in the encephalomyocarditis virus P3 region lethally abrogate the normal processing cascade,” J. Virol. (1996a) 70:5954-5961.
Hall, D.J., et al., “Mengo virus 3C proteinase: Recombinant expression, intergenus substrate cleavage and localization in vivo,” Virus Genes (1996) 13:99-110.
IRES Bicistronic Expression Vectors, for the rapid and efficient production of stable mammalian cell lines, CLONTECHniques Oct. 1996 Abstract.
Palmenberg, A.C., et al., “Alignments and comparative profiles of picornavirus genera,” Molecular Biology of Picornaviruses (Semler and Wimmer Eds.) (2001) 149-158.
Palmenberg, A.C., “Cardiovirus 2A localizes to nucleoli, upregulates rRNA . . . ,” Meeting talk and poster for S. Europic Picornavirus meeting May 17, 2002, Cape Cod, MA.
Svitkin, Y.V., et al., “Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus,” J. Virol. (1998) 72:5811-5819.
Aminev Aleksey G.
Groppo Rachel P.
Palmenberg Ann C.
Marvich Maria
Quarles & Brady LLP
Vinarov Sara D.
Wisconsin Alumni Research Foundation
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