Compositions and methods for regulating bacterial pathogenesis

Details Compositions and methods for regulating bacterial pathogenesis Compositions and methods for regulating bacterial pathogenesis

2005-01-18

2005-01-18

Duffy, Patricia A. (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S806000, C530S808000, C523S001000, C523S001000, C523S001000, C424S197110, C424S193100, C424S234100, C424S235100, C424S241100, C424S258100, C424S243100, C424S252100, C514S408000, C514S418000, C514S438000, C514S441000, C514S461000

Reexamination Certificate

active

06844423

ABSTRACT:
The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.

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