Compositions and methods for regulating bacterial pathogenesis

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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C435S069700, C435S320100, C435S006120, C435S029000, C435S004000, C435S468000, C435S476000, C536S024100, C536S023100, C536S023200, C536S023400, C530S350000

Reexamination Certificate

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ABSTRACT:
The production of a purified extracellular bacterial signal called autoinducer-2 is regulated by changes in environmental conditions associated with a shift from a free-living existence to a colonizing or pathogenic existence in a host organism. Autoinducer-2 stimulates LuxQ luminescence genes, and is believed also to stimulate a variety of pathogenesis related genes in the bacterial species that produce it. A new class of bacterial genes is involved in the biosynthesis of autoinducer-2.

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