Drug – bio-affecting and body treating compositions – Topical sun or radiation screening – or tanning preparations
Patent
1988-09-06
1990-03-06
Ore, Dale R.
Drug, bio-affecting and body treating compositions
Topical sun or radiation screening, or tanning preparations
424 60, 424 941, 514847, 514937, 514938, 514939, 514944, 514969, A61K 740, A61K 742, A61K 3748
Patent
active
049064576
ABSTRACT:
Compositions and methods for reducing the risk of skin cancer. The novel compositions include at least one effective protease inhibitor. Preferred protease inhibitors include serine protease inhibitors and metallo- protease inhibitors. The protease inhibitors are preferably included in concentrations ranging from approximately 10 picograms to 10 milligrams per milliliter of the skin-applicable topical mixtures. The topical mixtures preferably include a suitable topical vehicle such as a cream, lotion, or ointment. One class of anti-carcinogenic skin treatment compositions of this invention preferably includes the desired protease inhibitors in combination with a suitable sunscreen agent or agents, such as para-amino benzoic acid, to provide particularly advantageous compositions for reducing the risk of sunlight-induced skin cancer.
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Billings et al., "Inhibition of Radiation-Induced Transformation of C3H/10T1/2 Cells by Chymotrypsin Inhibitor 1 From Potatoes", Careinogenesis, vol. 8, No. 6, pp. 809-812.
Troll et al., "Tumorigenesis in Mouse Skin Inhibition by Synthetic Inhibitors of Proteases", Science, vol. 169, 18 Sep. 1970, pp. 1211-1213.
Hozumi et al., "Inhibition of Tumorigenesis in Mouse Skin by Leupeptin, a Protease Inhibitor from Actinomycetes", Cancer Research 32, Aug. 1972, pp. 1725-1728.
Ore Dale R.
Washington State University Research Foundation, Inc.
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