Compositions and methods for reducing the risk of epileptic...

Details Compositions and methods for reducing the risk of epileptic... Compositions and methods for reducing the risk of epileptic...

2004-08-12

2010-06-29

Davis, Zinna N (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S221000, C514S270000, C514S312000, C514S340000, C514S350000, C514S351000, C540S504000, C540S589000, C544S310000, C546S156000, C546S272700, C546S299000, C546S300000

Reexamination Certificate

active

07745426

ABSTRACT:
The present invention relates to compounds and compositions useful for reducing the risk of epileptic occurrences and/or for alleviating epileptic phenomena in patients. In accordance with the invention, the compounds and compositions have at least the following two components: a) vitamin B6-based component selected from pyridoxal, pyridoxamine, pyridoxine, their pharmaceutically acceptable functional derivatives and salts; and b) at least one antiepileptic drug (AED) or anticonvulsive, neuro-protective drug or nootrope compound or moiety. The invention further relates to methods for preventing epileptic episodes and for alleviating epileptic episodes, as well as methods for reducing side effects of antiepileptic drugs.

REFERENCES:
patent: WO 95/31194 (1995-11-01), None
patent: 0156609 (2001-08-01), None
patent: WO 01/56609 (2001-08-01), None
Dolina et at, Epilepsia (1993), 34(1), 33-42.
Dakshinamurti et al, Biochimica et Biophysica Acta, Proteins and Proteomics, (2003), 1647(1-2), 225-229.
Mueller, S.G. et al.“Influence of pyridoxal 5′-phosphate alone and in combination with vigabatrin on brain GABA measured by 1H-NMR-spectroscopy”Brain Research Bulletin, vol. 55, No. 4, pp. 555-560 (2001).
Takuma, Yuichi et al. “ACTH Therapy for Infantile Spasms: A Combination Therapy with High-Dose Pyridoxal Phosphate and Low-Dose ACTH”Epilepsia, vol. 39, Suppl. 5, pp. 42-45 (1998).
Supplementary Partial European Search Report issued in corresponding European Patent Application No. EP 04 77 0425.

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