Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Reexamination Certificate
2006-03-28
2006-03-28
Tsang, Cecilia J. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
C560S056000, C562S466000
Reexamination Certificate
active
07019034
ABSTRACT:
Diabetic mammals are treated with compounds that are significantly more efficacious as agonists of RXRβretinoid receptors than as agonists of RXRαor RXRγretinoid receptors. The treatment reduces serum glucose and triglyceride levels of the mammals without the undesirable side effects of reducing serum thyroxine levels and a transient increase in serum triglyceride levels Compounds suitable for use in the methods of treatments of the present invention are selected by testing and identifying compounds of selective or specific efficacy as agonists of RXRβretinoid receptors in preference over RXRαand/or RXRγretinoid receptors. Novel compounds used in the methods of the invention have Formula 1 where the variables are defined as disclosed in the specification.
REFERENCES:
patent: 5455265 (1995-10-01), Chandraratna
patent: 5801253 (1998-09-01), Klaus et al.
patent: 6114533 (2000-09-01), Vuligonda et al.
patent: 6759547 (2004-07-01), Beard et al.
patent: WO 93/11755 (1993-06-01), None
patent: WO 97/12853 (1997-04-01), None
patent: WO 01/19770 (2001-03-01), None
Mangelsdorf et al. (1994) The Retinoid Receptors In: The Retinoids, edited by SPORN et al. p319-349. Raven Press, Ltd., New York.
Okamura et al. Chemistry and Biology of Synthetic Retinoids, CRC Press Inc,. 1990, p324-356.
Mukherjee,R.; Davies, P.J.; Crombie, D.L. Bishoff, E.D.; Cesario, R.M.; Jow Hamann, L.G.; Boehm, M.F.; Mondon, C.E.; Nadzan, A.M.; Paterniti, J.R. Jr.; Heyman, R.A. Sensitization of Diabetic and Obese Mic to Insulin by Retinoid X Receptor Agonists.Nature1997, 386 (6623), 407-410.
J Amer. Chem. Soc. 1940, vol. 62, p. 36, p. 43.
Feigner P.L., Holm M. (1989) Focus, 11:2.
Heyman et al.Cell68, 397-406, (1992).
Allegretto et al. J. Biol. Chem. 268, 26625-26633, 1993.
Cheng et al. Biochemical Pharmacology, v. 22 pp 3099-3108, 1973.
Beard Richard L.
Chandraratna Roshantha A.
Yuan Yang-Dar
Allergan Inc.
Oh Taylor Victor
Szekeres Gabor L.
Tsang Cecilia J.
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