Compositions and methods for reducing respiratory depression...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S012200, C514S255040, C514S317000, C514S331000

Reexamination Certificate

active

06919350

ABSTRACT:
A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed delta/mu opioid agonist or a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a delta receptor agonist compound. Preferred examples of such delta receptor agonist compound include diarylmethyl piperazine compounds and diarylmethyl piperidine compounds, and pharmaceutical compositions thereof, having utility in medical therapy for reducing respiratory depression associated with certain analgesics, such as mu opiates.

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patent: 5574159 (1996-11-01), Chang et al.
patent: 5658908 (1997-08-01), Chang et al.
patent: 5681830 (1997-10-01), Chang et al.
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patent: 5854249 (1998-12-01), Chang et al.
patent: 5968551 (1999-10-01), Oshlack et al.
patent: 5985880 (1999-11-01), Chang et al.
patent: 6200978 (2001-03-01), Maw et al.
patent: 6300332 (2001-10-01), Chang et al.
patent: 208633 (1994-05-01), None
patent: 218673 (2000-10-01), None
patent: WO 98/52929 (1998-11-01), None
Database CAPLUS on STN, Dep. Pharmacology, University Michigan, (Ann Arbor, MI), Document No. 121:271967, Negus, S. et al., “Behavioral effects of the systematically active delta opioid agonist BW373U86 in rhesus monkeys,” abstract, J. Pharmacol. Exp. Ther., 270(3), 1025-1034, 1994.

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