Compositions and methods for reducing adhesiveness of defective

Details Compositions and methods for reducing adhesiveness of defective Compositions and methods for reducing adhesiveness of defective

1995-03-17

2000-09-26

Celsa, Bennett

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 14, 514 17, 530324, 530326, 530327, 530328, 530329, A61K 3800, C07K 500

Patent

active

061242624

ABSTRACT:
Peptide sequences and analogs thereof based on amino acid motifs in band 3 which are effective in reducing the adhesiveness of pathologically adhesive red blood cells. One class of peptide sequences are characterized by the sequence motif Z.sup.1 xKxxx+ (SEQ ID NO:45), wherein Z.sup.1 is selected from the group consisting of tyrosine, phenylalanine and alanine; x is an unobstructive residue and + is a positively charged residue (e.g., K or P--H). These peptides are used to reduce adhesiveness in the treatment of sickle cell disease, thalassemia and diabetes. A second class of peptide sequences are characterized by the sequence motif Z.sup.2 Z.sup.3 Z.sup.2 -x-xxxx- (SEQ ID NO:46), wherein Z.sup.2 represents a hydrophobic residue, x is an unobstructive residue and - is a negatively charged residue. These peptides can be used to reduce adhesiveness in the treatment of malria, sickle cell disease, thalassemia and diabetes.

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