Compositions and methods for propagation of neural...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Culture medium – per se

Reexamination Certificate

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C435S384000, C435S377000, C435S347000, C435S368000

Reexamination Certificate

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07632681

ABSTRACT:
Compositions and methods for the culturing, propagation, cryopreservation and manipulation of neural progenitor cells (NPC) and pluripotent stem cells (PSC) are provided. The cells exhibit rapid doubling times and can be maintained in vitro for extended periods. Also provided is a method of propagating neural progenitor cells, and a method of transplanting human NPC and/or PSC to a host. The cells can be genetically modified to express a therapeutic agent prior to the transplanting.

REFERENCES:
patent: 5750376 (1998-05-01), Weiss et al.
patent: 5753506 (1998-05-01), Johe
patent: 5843780 (1998-12-01), Thomson
patent: 5851832 (1998-12-01), Weiss et al.
patent: 5958767 (1999-09-01), Snyder et al.
patent: 5968829 (1999-10-01), Carpenter
patent: 5980885 (1999-11-01), Weiss et al.
patent: 5981165 (1999-11-01), Weiss et al.
patent: 6040180 (2000-03-01), Johe
patent: 6071889 (2000-06-01), Weiss et al.
patent: 6200806 (2001-03-01), Thomson
patent: 6238922 (2001-05-01), Uchida
patent: 6280718 (2001-08-01), Kaufman et al.
patent: 6294346 (2001-09-01), Weiss et al.
patent: 6399369 (2002-06-01), Weiss et al.
patent: 6468794 (2002-10-01), Uchida et al.
patent: 6497872 (2002-12-01), Weiss et al.
patent: 6498018 (2002-12-01), Carpenter
patent: 6602711 (2003-08-01), Thomson et al.
patent: 6610535 (2003-08-01), Lu et al.
patent: 6613568 (2003-09-01), Kaufman et al.
patent: 2001/0024825 (2001-09-01), Thomson
patent: 2002/0178460 (2002-11-01), Enikolopov et al.
patent: 2003/0008392 (2003-01-01), Thomson
patent: 2003/0013193 (2003-01-01), Wu
patent: 2003/0068819 (2003-04-01), Zhang et al.
patent: 2003/0073234 (2003-04-01), Amit et al.
patent: 2003/0166276 (2003-09-01), Carpenter
patent: 2003/0190748 (2003-10-01), Thomson
patent: 2004/0005701 (2004-01-01), Xu et al.
patent: 2004/0023376 (2004-02-01), Thomson et al.
patent: 2004/0224401 (2004-11-01), Ludwig et al.
patent: WO 94/10292 (1994-05-01), None
Pluchino S, Zanotti L, Deleidi M, Martino G.2005. Neural stem cells and their use as therapeutic tool in neurological disorders. Brain Res Brain Res Rev. Apr.;48(2):211-9.
Gerlach M, Braak H, Hartmann A, Jost WH, Odin P, Priller J, Schwarz J.2002. Current state of stem cell research for the treatment of Parkinson's disease. J Neurol. Oct.;249 Suppl 3:III/33-III-35.
Wobus AM, Boheler KR.2005.Embryonic stem cells: prospects for developmental biology and cell therapy. Physiol Rev. Apr.;85(2):635-78.
Stanworth SJ, Newland AC. 2001. Stem cells: progress in research and edging towards the clinical setting .Clin Med. Sep.-Oct.;1(5):378-82.
Thomas CE, Ehrhardt A, Kay MA. 2003. Progress and problems with the use of viral vectors for gene therapy. Nat Rev Genet. May;4(5):346-58.
Wolff JA, Fisher LJ, Xu L, Jinnah HA, Langlais PJ, Iuvone PM, O'Malley KL, Rosenberg MB, Shimohama S, Friedmann T, et al.Grafting fibroblasts genetically modified to produce L-dopa in a rat model of Parkinson disease.Proc Natl Acad Sci U S A. Nov. 1989;86(22):9011-4.
Metz GA, Tse A, Ballermann M, Smith LK, Fouad K. The unilateral 6-0HDA rat model of Parkinson's disease revisited: an electromyographic and behavioural analysis. Eur J Neurosci. Aug. 2005;22(3):abstract.
Eslamboli A.Marmoset monkey models of Parkinson's disease: which model, when and why? Brain Res Bull. Dec. 30, 2005;68(3):140-9. Epub Sep. 7, 2005.
Mandel RJ, Rendahl KG, Snyder RO, Leff SE. Progress in direct striatal delivery of L-dopa via gene therapy for treatment of Parkinson's disease using recombinant adeno-associated viral vectors.Exp Neurol. Sep. 1999;159(1):47-64. Review.
Littlefield JW. Stepwise aggregation, compaction, and differentiation of uncompacted F9 cells. Dev Genet. 1989;10(5):402-10.
Online Product search results for basic FGF, R & D Systems, printed Apr. 11, 2007. p. 1.
Online Product search results for TGF alpha, R & D Systems, printed Apr. 11, 2007. p. 1.
Online Product search results for EGF, R & D Systems, printed Apr. 11, 2007. p. 1.
Online product literature for GIBCO Advanced D-MEM/F-12, printed Apr. 11, 2007, pp. 1-2.
Keirstead HS.Stem cells for the treatment of myelin loss. Trends Neurosci. Dec. 2005;28(12):677-83. Epub Oct. 5, 2005.
Yves Benniger et al., “Differentiation and Histological Analysis of Embryonic Stem Cell-derived Neural Transplants in Mice”,Brain Pathology, 10: 330-341, 2001.
Christopher R. R. Bjornson et al., “Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo”,Science, 283: 534-537, Jan. 22, 1999.
M. K. Carpenter, “Enrichment of Neurons and Neural Precursors from Human Embryonic Stem Cells”,Exp Neurol, 172(2):383-97, Dec. 2001, (1-Page Abstract Only).
Constance G. Craig et al., “In Vivo Growth Factor Expansion of Endogenous Subependymal Neural Precursor Cells Populations in the Adult Mouse Brain”,The Journal of Neuroscience, 16(8):2649-2658, Apr. 15, 1996.
Rosemary A. Fricker et al., “Site-Specific Migration and Neuronal Differentiation of Human Neural Progenitor Cells after Transplantation in the Adult Rat Brain”,The Journal of Neuroscience, 19(14):5990-6005, Jul. 15, 1999.
Nicholas Galano et al., “Transplantation as a Tool to Study Progenitors within the Vertebrate Nervous System”,J. Neurobiol., 36(2):152-61, Aug. 3, 1998.
Angela Gritti et al., “Multipotential Stem Cells from the Adult Mouse Brain Proliferate and Self-Renew in Response to Basic Fibroblast Growth Factor”,The Journal of Neuroscience, 16(3):1091-1100, Feb. 1, 1996.
H. Georg Kuhn et al., “Neurogenesis in the Dentate Gyrus of the Adult Rat Age-Related Decrease of Neuronal Progenitor Proliferation”,The Journal of Neuroscience, 16(6):2027-2033, Mar. 15, 1996.
H. Georg Kuhn et al., “Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain”,The Journal of Neuroscience, 17(15) 5820-5829, Aug. 1, 1997.
Randall D. Learish et al., “Rat Neurospheres Express mRNAs for TrkB, BDNF, NT-3 and p75”,Molecular Tools for Neuroscience, Neural Notes Issue 19: 18-19, 2001.
Laura Lillen et al., “BMP and FGF Regulate the Development of EGF-responsive Neural Progenitor Cells”,Development, 127: 4993-5005, (2000) printed in Great Britain © The Company of Biologists Limited 2000.
A. Martinez-Serrano et al., “Human Neural Stem and Progenitor Cells: in Vitro and in Vivo Properties, and Potential for Gene Therapy and Cell Replacement in the CNS”,Curr Gene Ther., 1(3):279-99, Sep. 2001, (1-Page Abstract Only).
Eva Mezey et al., “Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow”,Science, 290: 1779-1782, Dec. 1, 2000.
Lars Olson, “Grafts and Growth Factors in CNS”,Proceedings of the Xth Meeting of the World Society for Sterotactic and Functional Neurosurgery, Maebashi, Japan, Oct. 1989,Stereotact Funct Neurosurg1990;54+55:250-267.
Kook In Park et al., “Transplantation of Neural Progenitor and Stem Cells: Developmental Insights May Suggest New Therapies for Spinal Cord and Other CNS Dysfunction”,Journal of Neurotrauma, 16(8), 1999.
Benjamin E. Reubinoff et al., “Embryonic Stem Cell Lines from Human Blastocysts: Somatic Differentiation in Vitro”,Nature Biotechnology, 18: 399-404, Apr. 2000.
Clive N. Svendsen et al, “Long-Term Survival of Human Central Nervous System Progenitor Cells Transplanted into a Rat Model of Parkinson's Disease”,Experimental Neurology, 148: 135-146, 1997.
Clive N. Svendsen et al., “A New Method for the Rapid and Long Term Growth of Human Neural Precursor Cells”,Journal of Neuroscience Methods, 85: 141-152, 1998.
James A. Thomson et al., “Embryonic Stem Cell Lines Derived from Human Blastocysts”,Science, 282: 1145-1147, Nov. 6, 1998.
Vincent Tropepe et al., “Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon”,Developmental Biology, 208: 166-188, 1999.
Christian Winkler et al., 

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