Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Monoclonal antibody or fragment thereof
Reexamination Certificate
2005-04-19
2005-04-19
Kemmerer, Elizabeth (Department: 1647)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Monoclonal antibody or fragment thereof
C514S183000, C514S330000, C514S423000, C514S428000, C514S465000, C514S466000
Reexamination Certificate
active
06881409
ABSTRACT:
FK506 and geldanamycin promote nerve regeneration by a common mechanism that involves the binding of these compounds to polypeptide components of steroid receptor-complexes other than the steroid hormone binding portion of the complex (FKBP52 and hsp90, respectively). These and other agents cause hsp90 dissociation from steroid receptor complexes or block association of hsp90 with steroid receptor complexes.
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Kemmerer Elizabeth
Klarquist & Sparkman, LLP
Nichols Christopher James
Oregon Health and Science University
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