Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-10-24
1999-10-19
Weddington, Kevin E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514330, 514423, 514428, 514465, 514466, 514534, 514547, 514548, 514549, A61K 3133, A61K 31445, A61K 3140, A61K 3136
Patent
active
059689218
ABSTRACT:
FK506 and geldanamycin promote nerve regeneration by a common mechanism that involves the binding of these compounds to polypeptide components of steroid receptor complexes other than the steroid hormone binding portion of the complex (FKBP52 and hsp90, respectively). These and other agents cause hsp90 dissociation from steroid receptor complexes or block association of hsp90 with steroid receptor complexes.
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Orgegon Health Sciences University
Weddington Kevin E.
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