Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2008-07-22
2008-07-22
Yu, Misook (Department: 1642)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
Reexamination Certificate
active
11065139
ABSTRACT:
The present invention provides compositions and methods of using the EPHB2 gene or its related signaling pathways to detect, prognosticate, assess the risk of, prevent, or treat cancers. Cancers amenable to the present invention include, but are not limited to, prostate cancer, breast cancer, and neuroblastoma. In one aspect, the present invention provides compositions which comprise an agent capable of eradicating or alleviating an abnormality in the EPHB2 gene or its related signaling pathways. This abnormality may cause or contribute to the development or progression of cancers. In another aspect, the present invention provides methods comprising detecting an abnormality in the EPHB2 gene or its related signaling pathways. The presence or absence of such an abnormality is indicative of the risk or disease status of cancer in a person of interest.
REFERENCES:
Tockman et al (Cancer Res., 1992, 52:2711s-2718s).
Kittles et al (JMG online, Sep. 9, 2005, 1-11), (1-13).
Aguirre-Ghiso et al (Cancer Research, 63:1684-1695).
Kittles et al (JMG online, Sep. 9, 2005, 1-11),(1-13).
Aquirre-Ghiso et al (Cancer Research, 63:1684-1695).
Azorsa David O.
Carpten John D.
Huusko Pia
Kallioniemi Olli
Kiefer Jeffrey
Aeder Sean
Dyke Raymond Van
Jackson Jeffrey M.
The Translational Genomics Research Institute (TGen)
Winston & Strawn LLP
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