Compositions and methods for producing vascular occlusion...

Details Compositions and methods for producing vascular occlusion... Compositions and methods for producing vascular occlusion...

2005-11-01

2005-11-01

Chan, Christina (Department: 1644)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

C424S489000, C424S490000, C424S491000, C530S350000, C530S395000, C530S380000, C530S391100

Reexamination Certificate

active

06960352

ABSTRACT:
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.

REFERENCES:
patent: WO 00/29029 (2000-05-01), None
Sundfor, K. et al. Gynecologic Oncology [1997] 64:230-236.
Paul Jurasz et al., “Role of Von Willebrand factor in tumour cell-induced platelet aggregation: differential regulation by NO and prostacyclin”, British Journal of Pharmacology, vol. 134, No. 5, Nov. 2001, pp. 1104-1112.

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