Compositions and methods for preventing and treating rotaviral i

Details Compositions and methods for preventing and treating rotaviral i Compositions and methods for preventing and treating rotaviral i

1989-12-13

1991-10-01

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

A61K 31575

Patent

active

050534068

ABSTRACT:
Compositions useful in the prevention and treatment of rotaviral infections are disclosed. The subject compositions contain cholesterol 3-sulfate or functional derivatives thereof. Cholesterol 3-sulfate avidly binds rotavirus in thin layer overlay assays and inhibits rotavirus in plaque reduction assays. These compositions can be used to prevent and ameliorate rotaviral infections.

REFERENCES:
Yolken et al., J. Clin. Invest. (1987) 79:148-154.
Willoughby et al., Abstracts of the Proceedings of U.S.-Japan International Rotavirus Meeting, Anapolis, Md. (Aug. 1989).
Lecce et al., Infect. Immunol. (1976) 14:816-825.
Mebus et al., Infect. Immunol. (1976) 14:471-474.
Wyatt et al., Science (1980) 207:189-191.
Jetten et al., J. Invest. Dermatol. (1989) 92:203.
Nichols et al., J. Lipid Res. (1988) 29:1205.

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