Compositions and methods for PACE 4 and 4.1 gene and polypeptide

Details Compositions and methods for PACE 4 and 4.1 gene and polypeptide Compositions and methods for PACE 4 and 4.1 gene and polypeptide

1994-08-02

1999-01-26

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 681, 435 694, 435 701, 435 703, 435 711, 435 712, 435226, 4352523, 4352402, 43525411, 4352542, 4353201, 536 232, 536 231, 536 235, C12N 1557, C12N 964, C12N 1500

Patent

active

058637567

ABSTRACT:
Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These compositions and methods utilize recombinant PACE 4 and 4.1, mammalian endopeptidases that are specific for dibasic amino acid sites. Therapeutic compositions and methods employing PACE 4 or 4.1 or their inhibitors are also provided.

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