Compositions and methods for PACE 4 and 4.1 gene and polypeptide

Details Compositions and methods for PACE 4 and 4.1 gene and polypeptide Compositions and methods for PACE 4 and 4.1 gene and polypeptide

1995-05-23

1999-11-23

Prouty, Rebecca E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

424 9464, 536 232, 536 234, 530350, C12N 964, A61K 3848

Patent

active

059898909

ABSTRACT:
Compositions and methods are provided for endopeptidases and their production, and for enhanced efficiencies of processing heterologous precursor polypeptides to mature polypeptides. These compositions and methods utilize recombinant PACE 4 and 4.1, mammalian endopeptidases that are specific for dibasic amino acid sites. Therapeutic compositions and methods employing PACE 4 or 4.1 or their inhibitors are also provided.

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