Compositions and methods for p53-mediated repression of gene...

Details Compositions and methods for p53-mediated repression of gene... Compositions and methods for p53-mediated repression of gene...

2006-05-30

2006-05-30

Ketter, James (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100

Reexamination Certificate

active

07053194

ABSTRACT:
Compositions and methods are provided for identifying novel therapeutic agents for the treatment of cancer and other cellular proliferative disorders.

REFERENCES:
Bao, R. et al. “Activation of Cancer-Specific Gene Expression by the Survivin Promoter”; Journal of the National Cancer Institute, 94(7): 522-528 (2002).
Hoffman, W.H. et al. “Transcriptional Repression of the Anti-apoptoticsurvivinGene by Wild Type p53”, 277(5): 3247-3257 (2002).
Yang, L. et al. “Tumor-specific gene expression using the survivin promoter is further increased by hypoxia”; Gene Therapy, 11: 1215-1233 (2004).

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