Compositions and methods for modulating the effect of TNF and IL

Details Compositions and methods for modulating the effect of TNF and IL Compositions and methods for modulating the effect of TNF and IL

1987-09-09

1993-05-18

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Lymphokine

424 852, 424 854, 424 855, 424 856, 424 857, 514 2, 514 8, 514885, A61K 3702

Patent

active

052119459

ABSTRACT:
This invention relates to methods for modulating the effects of TNF and IL-1, both the deleterious and the therapeutical effect of these cytokines. In case of deleterious effects, the invention provides methods for modulating the deleterious effect of TNF and/or IL-1 in mammals, by administering to a mammal sub-deleterious amounts of TNF and/or IL-1. The TNF and/or IL-1 to be modulated may be endogenous, i.e. generated in the organism in severe cases in amounts deleterious to the organism, or exogenously administered to a patient in amounts which are potentially deleterious. The compositions of the invention comprise effective amounts of TNF and/or IL-1 with at least one pharmaceutically acceptable carrier. The invention also relates to methods for monitoring the modulation of the TNF effect in patients treated with TNF and/or IL-1.

REFERENCES:
patent: 4863727 (1989-09-01), Zimmerman et al.
patent: 4879111 (1989-11-01), Chong
patent: 4948875 (1990-08-01), Tanaka et al.
patent: 4980160 (1990-12-01), Goldberg et al.
Beutler et al, Science, 229, 1985, pp. 869-871.
Moore et al, PNAS, 84, 1987, pp. 7134-7138.
Santoli et al, J Immunol, 139, 1987, pp. 3348-3354.
Beutler et al, Nature, 320, 1985, pp. 584-588.
Immune Modulation Agents and Their Mechanisms, ed Fenichel et al, 1984 (index only).
Philip, Nature, 323, 1986, pp. 86-89.
Old, Nature 326 1987, pp. 330-331.
Neta et al, J Immunol 136(7) 1986, p. 2483.
Itano et al, CA vol. 108, 1988, #15896u.
Seelentag et al EMBO Journal 1987, pp. 2261-2265.
Bachwich et al BBRC 136, 1986, pp. 94-101.
Kawakami et al BBRC 141, 1986, pp. 482-487.
Ghiara et al, J Immunol, vol. 139, 1987, pp. 3676-3679.
Wallach, "Cytotoxins (Tumour Necrosis Factor, Lymphotoxin and Others): Molecular and Functional Characteristics and Interactions with Interferons", Interferon 7 (ed. Gresser), pp. 89-124 (1986, Academic Press, London).
Israel et al "Binding of Human TNF-.alpha. to High-Affinity Cell Surface Receptors: Effect of IFN", Immunology Letters, 12:217-27 (1986).
Wallach, "Preparations of Lymphotoxin Induce Resistance to Their Own Cytotoxic Effect", T. Immunology 132:2464-69 (1984).

Affiliated with

Also associated with

Rating

Compositions and methods for modulating the effect of TNF and IL does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for modulating the effect of TNF and IL, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for modulating the effect of TNF and IL will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-802953