Compositions and methods for modulating RNA activity through mod

Details Compositions and methods for modulating RNA activity through mod Compositions and methods for modulating RNA activity through mod

1994-10-21

1997-07-01

Rories, Charles C. P.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

536 245, 536 187, 514 44, 435 6, 435325, 424604, 424617, C12N 510, C07H 2100, C08B 3700, A01N 5916

Patent

active

056437803

ABSTRACT:
Methods for regulating gene expression in biological experimental systems via modification or removal of the 5' cap structure of targeted ribonucleic acids are disclosed. Modification or removal of the 5' cap structure is achieved in accordance with preferred embodiments utilizing antisense compounds which are complementary to the 5' terminus of the targeted RNA and have attached to them reactive moieties explicitly designed for chemical modification or cleavage of the 5' cap structure of RNA. Compositions that have utility as research reagents and therapeutics for the treatment of diseases are disclosed.

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