Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-05-24
2011-05-24
Chernyshev, Olga N (Department: 1649)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S001000, C514S001100, C514S021200
Reexamination Certificate
active
07947652
ABSTRACT:
The present invention provides methods for modulating mitochondrial function, modulating lesion formation in the brain, modulating neurite growth, modulating neuronal degeneration, and treating and preventing neurological diseases or disorders comprising modulating the expression or activity of PGC-1α. The present invention also provides an animal, e.g., transgenic mouse, in which the PGC-1α gene is misexpressed. Methods for identifying compounds which are capable of treating or preventing a neurological disease or disorder are also described.
REFERENCES:
patent: 6525178 (2003-02-01), Spiegelman et al.
patent: WO-02/062297 (2002-08-01), None
patent: WO-2004/000313 (2003-12-01), None
Chaturverdi et al., 2009, Human Mol. Genetics, vol. 18, No. 16, pp. 3048-3065.
Aoki, T. T., “Metabolic Adaptations to Starvation, Semistarvation, and Carbohydrate Restriction,” Prog Clin Biol Res 67:161-177 (1981).
Baar et al., “Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC-1,” FASEB Journal, 1879-1886 (2002).
Bouillaud, F. et al., “Molecular approach to thermogenesis in brown adipose tissue: cDNA cloning of the mitochondrial uncoupling protein,” Proc Natl Acad Sci USA 82:445-448 (1985).
Carling, D., “The AMP-activated protein kinase cascade—a unifying system for energy control,” Trends Biochem Sd 29:18-24 (2004).
Croniger, C. et al., “Role of the Isoforms of CCAAT/Enhancer-binding Protein in the Initiation of Phosphoenolpyruvat Carboxykinase (GTP) Gene Transcription at Birth,” J Biol Chem 272:26306-26312 (1997).
Croniger, C. et al., “C/EBP and the Control of Phosphoenolpyruvate Carboxykinase Gene Transcription in the Liver,” J Biol Chem 273:31629-31632 (1998).
Fan, M., et al., “Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α: modulation by p38 MAPK,” Genes Dev 18:278-289 (2004).
Goto et al., “cDNA Cloning and mRNA Analysis of PGC-1 in Epitrochlearis Muscle in Swimming-Exercised Rats,” Biochem Biophys Res Commun 274, 350-354 (2000).
Hanson, R. W., and Reshef, L., “Regulation of Phosphoenolpyruvate Carboxykinase (GTP) Gene Experssion,” Annu Rev Biochem 66:581-611 (1997).
Herzig, S., et al., “CREB regulates hepatic gluconeogenesis through the coactivator PGC-1,” Nature 413:179-183 (2001).
Horton, J. D., et al., “SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver,” J Clin Invest 109:1125-1 131 (2002).
Jacobsson, A., et al., Mitochondrial Uncoupling Protein from Mouse Brown Fat, J Biol Chem 260:16250-16254 (1985).
Kelly, D. P., and Scarpulla, R. C., “Transcriptional regulatory circuits controlling mitochondrial biogenesis and function,” Genes Dev 18:357-368 (2004).
Lehman et al, “Peroxisome proliferator-activated receptor γ coactivator-1 promotes cardiac mitochondrial biogenesis,” J Clin Invest 106:847-856 (2000).
Lehman et al., “Transcriptional Activation of Energy Metabolic Switches in the Developing and Hypertrophied Heart,” Clin. Exp. Pharmacol. Phys. 29:339-345 (2002).
Lewandoski, M. et al., “Zp3-cre, a transgenic mouse line for the activation or inactivation ofIoxP-flanked target genes specifically in the female germ line,” Curr Biol 7, 148-151 (1997).
Lin et al., “Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres,” Nature 418:797-801 (2002).
Liu, S. et al., Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPβ gene, J Clin Invest 103:207-213 (1999).
Miyake, K., et al., “Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver,” J Clin Invest 110:1483-1491 (2002).
Mootha et al., “PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes,” Nat. Genet., 34:267-273 (2003).
Moyes, C.D., “Controlling muscle mitochondrial content,” Exp. Biol. 206:4385-4391 (2003).
Park, E. A. et al., “Relative Roles of CCAAT/Enhancer-binding Protein β and cAMP Regulatory Element-binding Protein in Controlling Transcription of the Gene for Phosphoenolpyruvate Carboxykinase (GTP),” J Biol Chem 268:613-619 (1993).
Patti, M. et al., “Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1,” PNAS 100:8466-8471 (2003).
Pilkis, S. J., and Granner, D. K., “Molecular Physiology of the Regulation of Hepatic Gluconeogenesis and Glycolysis,” Annu Rev Physiol 54:885-909 (1992).
Portilla, D., “Energy Metabolism and Cytotoxicity,” Seminars Nephrol. 23:432-438 (2003).
Puigserver et al. A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis, Cell 92:829-839 (1998).
Puigserver, P.,and Spiegelman, B.M., “Peroxisome Proliferator-Activated Receptor-γ Coactivator 1α (PGC-1α): Transcriptional Coactivator and Metabolic Regulator,” Endocrine Rev 24:78-90 (2003).
Rhee, J., et al., “Regulation of hepatic fasting response by PPARγ coactivator-1α (PGC10): Requirement for hepatocyte nuclear factor 4α in gluconeogenesis,” PNAS 100:4012-4017 (2003).
Roesler, W. J., “The Role of C/EBP in Nutrient and Hormonal Regulation of Gene Expression,” Annu Rev. Nutr 21:141-165 (2001).
Schilling, G. et al., “Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin,” Human Mol. Genet. 8(3):397-407 (1999).
Schon, E.A. and Manfredi, G., “Neuronal degeneration and mitochondrial dysfunction,” J. Clin. Invest. 111(3):303-312 (2003).
Shin, D. J., et al., “PGC-1α Activates CYP7A1 and Bile Acid Biosynthesis,” J Biol Chem 278:50047-50052 (2003).
St-Pierre et al., “Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells,” J Biol Chem 278:26597-26603 (2003).
Tritos et al., “Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1α) expression in the murine brain,” Brain Res. 961:255-260 (2003).
Wu, Z., “Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1,” Cell 98:115-124 (1999).
Yoon et al., “Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1,” Nature 413:131-138 (2001).
Presentation “Control of Lipid and Energy Homeostasis Through Transcriptional Coactivation” presented at Northwestern Medical School on Jun. 8, 2004 (9 pages).
Houten et al., “PGC-1α: Turbocharging Mitochondria,” Cell, 119(1):5-7 (2004) XP-002551130.
Koo et al., “PGC-1 promotes insulin resistance in liver through PPAR-α-dependent induction of TRB-3,” Nature Medicine, 10(5):530-534 (2004).
Leone et al., “PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis,” PloS Biology, 3(4):672-687 (2005).
Lin et al., “Defects in Adaptive Energy Metabolism with CNS-Linked Hyperactivity in PGC-1α Null Mice,” Cell, 119(1):121-135 (2004).
Lin et al., “Metabolic control through the PGC-1 family of transcription coactivators,” Cell Metabolism, 1(6):361-370 (2005).
Supplemental European Search Report dated Oct. 30, 2009 from Application No. 05809824.5.
GenBank Accession No. NM—013261 (GI: 29570796) dated Sep. 24, 2006.
GenBank Accession No. NM—008904 (GI: 6679432) dated Oct. 14, 2007.
Lin Jiandie
Spiegelman Bruce M.
Chernyshev Olga N
Dana-Farber Cancer Institute Inc.
Foley & Hoag LLP
LandOfFree
Compositions and methods for modulating PGC-1α to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Compositions and methods for modulating PGC-1α to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for modulating PGC-1α to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2673535