Compositions and methods for modulating connexin hemichannels

Details Compositions and methods for modulating connexin hemichannels Compositions and methods for modulating connexin hemichannels

2006-12-26

2006-12-26

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07153822

ABSTRACT:
Disclosed are compositions and methods for modulating hemichannel function in a cell, tissue or organ. The invention also relates to useful screens for detecting such compounds, particularly those capable of modulating connexin phosphorylation. Further provided are therapeutic methods for preventing or treating conditions impacted by undesired hemichannel function in a mammal such as heart arrhythmia.

REFERENCES:
patent: 3740438 (1973-06-01), Cook et al.
patent: 3862113 (1975-01-01), Riniker et al.
patent: 4340592 (1982-07-01), Adibi
patent: 4636492 (1987-01-01), Kettner et al.
patent: 4652552 (1987-03-01), Kettner et al.
patent: 4666890 (1987-05-01), Kitaura et al.
patent: 4797471 (1989-01-01), Teetz et al.
patent: 5037957 (1991-08-01), Grubb et al.
patent: 5047401 (1991-09-01), Lipsky et al.
patent: 5061710 (1991-10-01), Haslanger et al.
patent: 5206221 (1993-04-01), Lipsky et al.
patent: 5223486 (1993-06-01), Gordon et al.
patent: 5252560 (1993-10-01), Myers et al.
patent: 5432159 (1995-07-01), Repolles Moliner et al.
patent: 5446023 (1995-08-01), Pavia et al.
patent: 5492894 (1996-02-01), Bascom et al.
patent: 5492916 (1996-02-01), Morriello et al.
patent: 5492920 (1996-02-01), Chen et al.
patent: 5494919 (1996-02-01), Morriello et al.
patent: 5514694 (1996-05-01), Powers et al.
patent: 5534538 (1996-07-01), Drauz et al.
patent: 5543397 (1996-08-01), Drauz et al.
patent: 5602102 (1997-02-01), Thiele et al.
patent: 5610297 (1997-03-01), Powers
patent: 5622973 (1997-04-01), Morriello et al.
patent: 5637564 (1997-06-01), Pavia et al.
patent: 5643955 (1997-07-01), Kurtz et al.
patent: 5650393 (1997-07-01), Pavia et al.
patent: 5650508 (1997-07-01), Powers
patent: 5798442 (1998-08-01), Gallant et al.
patent: 5811387 (1998-09-01), Simon et al.
patent: 5849711 (1998-12-01), Tung et al.
patent: 5872101 (1999-02-01), Munoz et al.
patent: 5877182 (1999-03-01), Nargund et al.
patent: 5980913 (1999-11-01), Penney
patent: 6017925 (2000-01-01), Duggan
patent: 6136787 (2000-10-01), Black et al.
patent: 6162828 (2000-12-01), Fukuda et al.
patent: 6187906 (2001-02-01), Gluckman et al.
patent: 6235929 (2001-05-01), Powers
patent: 6251625 (2001-06-01), Bommarius et al.
patent: 6255285 (2001-07-01), Kotake et al.
patent: 6291640 (2001-09-01), Bailey et al.
patent: 6342481 (2002-01-01), Leoni et al.
patent: 6353023 (2002-03-01), Larsen et al.
patent: 6358978 (2002-03-01), Ritzeler et al.
patent: 6384272 (2002-05-01), Stammler et al.
patent: 6410585 (2002-06-01), Larsen et al.
patent: 6780848 (2004-08-01), Gluckman et al.
patent: 6888022 (2005-05-01), Audia et al.
patent: 2001/0020006 (2001-09-01), Hans-Ulrich et al.
patent: 2002/0049164 (2002-04-01), Demuth et al.
patent: 2002/0169133 (2002-11-01), Dankwardt et al.
patent: 2003/0050247 (2003-03-01), Kuhner et al.
patent: 2003/0092609 (2003-05-01), Larsen et al.
patent: 2003/0092634 (2003-05-01), Buysse et al.
patent: 2003/0105165 (2003-06-01), Griffith
patent: 2003/0114387 (2003-06-01), Castro Pineiro et al.
patent: 2003/0135023 (2003-07-01), Demuth et al.
patent: 2003/0194445 (2003-10-01), Kuhner et al.
patent: 2003/0202989 (2003-10-01), Collier et al.
patent: 2003/0228353 (2003-12-01), Cowsar
patent: 2004/0005304 (2004-01-01), Brudnak
patent: 2004/0029796 (2004-02-01), Szeto et al.
patent: 2004/0092429 (2004-05-01), Jensen et al.
patent: 2004/0102609 (2004-05-01), Chatterjee et al.
patent: 2004/0106560 (2004-06-01), Sundstrom et al.
patent: 2004/0121964 (2004-06-01), Madar et al.
patent: 2004/0127427 (2004-07-01), Powers et al.
patent: 2004/0142876 (2004-07-01), Colarusso et al.
patent: 2004/0167106 (2004-08-01), Rodriguez et al.
patent: 2004/0167201 (2004-08-01), Sharma et al.
patent: 2004/0171555 (2004-09-01), Demuth et al.
patent: 2004/0235752 (2004-11-01), Pitt et al.
patent: 2005/0020482 (2005-01-01), Phipps et al.
patent: 2005/0059608 (2005-03-01), Jarvinen et al.
patent: 2005/0075280 (2005-04-01), Larsen et al.
patent: 2005/0107308 (2005-05-01), Posposilik et al.
patent: 2005/0113293 (2005-05-01), Larsen et al.
patent: 2156618 (1994-10-01), None
patent: 41 22 885 (1993-01-01), None
patent: 43 14 260 (1994-11-01), None
patent: 198 16 932 (1999-10-01), None
patent: 93/14777 (1993-08-01), None
patent: 94/03468 (1994-02-01), None
patent: 94/12181 (1994-06-01), None
patent: 94/14817 (1994-07-01), None
patent: 94/15908 (1994-07-01), None
patent: 95/13069 (1995-05-01), None
patent: 96/19494 (1996-06-01), None
patent: WO 9621674 (1996-07-01), None
patent: 96/30395 (1996-10-01), None
patent: 96/33209 (1996-10-01), None
patent: 97/05889 (1997-02-01), None
patent: 98/10653 (1998-03-01), None
patent: 98/31359 (1998-07-01), None
patent: 99/11606 (1999-03-01), None
patent: 99/31049 (1999-06-01), None
patent: WO 00/75286 (2000-12-01), None
patent: 01/00610 (2001-01-01), None
patent: WO 01/62775 (2001-08-01), None
patent: 01/90085 (2001-11-01), None
patent: 01/92236 (2001-12-01), None
patent: 02/077017 (2002-10-01), None
patent: WO 02/077017 (2002-10-01), None
patent: 02/101007 (2002-12-01), None
patent: 2004/028466 (2004-04-01), None
patent: 2004/048400 (2004-06-01), None
Lampe et al. Regulation of Gap Junctions by Phosphorylation of Connexins. Archives of Biochemistry and Biophysics. Dec. 15, 2000. vol. 384. No. 2, pp. 205-215.
Actions of the antiarrythmic peptide AAP10 on intercellular coupling. Naunyn Schmiedebergs Arch Pharmacol. Jul. 1997; vol. 356, No. 1., pp. 76-82.
A. C. Campos de Carvalbo, et al., “Conduction Defects And Arrhythmias In Chagas' Disease: Possible Role Of Gap Junctions And Humoral Mechanisms”, Journal of Cardiovascular Electrophysiology, vol. 5, No. 8, Aug. 1994, pp. 686-698.
R. R. Kaprielian, et al., “Downregulation Of Immunodetectable Connexin43 And Decreased Gap Junction Size In The Pathogenesis Of Chronic Hibernation In The Human Left Ventricle”, Circulation 97, 1998,pp. 651-660.
N. S. Peters, et al. “Reduced Content Of Connexin43 Gap Junctions In Ventricular Myocardium From Hypertrophied And Ischemic Human Hearts”, Circulation, vol. 88, No. 3, Sep. 1993, pp. 864-875.
J. E. Saffitz, et al. “Mechanisms Of Remodeling Of Gap Junction Distributions And The Development Of Anatomic Substrates Of Arrhythmias”, Cardiovascular Research 42 (1999) pp. 309-317.
Bruzzone, R. et al. “Connections With Connexins: The Molecular Basis Of Direct Intercellular Signaling”, Eur. J. Biochem. 238, pp. 1-27 (1996).
Darrow, B. J. et al. “Expression Of Multiple Connexins In Cultured Neonatal Rat Ventricular Myocytes”, Circulation Research, vol. 76, (3), (1995), 18 pages.
Wang, Y. et al. “Inhibition Of Glycosylation Induces Formation Of Open Connexin-43 Cell-to-Cell Channels And Phosphorylation And Triton X-100 Insolubility Of Connexin-43”, The Journal Of Biological Chemistry, vol. 270, No. 44, Nov. 3, 1995, pp. 26581-26585.
Yamanaka, I. et al. “Changes In The Phosphorylation States Of Connexin43 In Myoepithelial Cells Of Locating Rat Mammery Glands”, European Journal Of Cell Biology, vol. 72, pp. 166-173 (Feb. 1997).
Kondo et al. “Metabolic Inhibition Activates A Non-Selective Current Through Connexin Hemichannels In Isolated Ventricular Myocytes”, J. Mol. Cell. Cardiol. 32, pp. 1859-1872 (2000).
Li, F. et al. “Activation Of Connexin-43 Hemichannels Can Elevate [Ca2+]1 And [Na+]1 In Rabbit Ventricular Myocytes During Metabolic Inhibition”, J. Mol. Cell. Cardiol. 33, pp. 2145-2155 (2001).
Beardslee, M. A. et al. “Dephosphorylation And Intracellular Residtribution Of Ventricular Connexin43 During Electrical Uncoupling Induced By Ischemia”, Circ. Res. 87, pp. 656-662, Oct. 13, 2000.
Lin, R. et al. “v-Src Phosphorylation Of Connexin 43 On Tyr247 And Tyr265 Disrupts Gap Junctional Communication”, The Journal Of Cell Biology 154 (4), pp. 815-827 (2001).
Mohammad Z. Hossain, et al. “Regulation Of Cx43 Gap Junctions: The Gatekeeper And The Password”, (published Oct. 17, 2000) Science's Stke, Perspective, five pages.
Tomoko Nao, et al. “Alteration Of Gap Junction Proteins

Affiliated with

Also associated with

Rating

Compositions and methods for modulating connexin hemichannels does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for modulating connexin hemichannels, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for modulating connexin hemichannels will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3706764