Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-02-18
1999-08-03
Degen, Nancy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 4, 514 2, 530300, 530326, 530327, 530328, G01N 3353, A01N 3718, A61K 3800, C12Q 100
Patent
active
059324252
ABSTRACT:
Compositions and methods for modulating the activation of nuclear factor .kappa.B (NF-.kappa.B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I.kappa.B.alpha. and/or I.kappa.B.beta.. Such compositions may be used for treating diseases associated with NF-.kappa.B activation. Modulating agents include peptides that comprise a recognition domain for E3 ubiquitin ligase.
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Alkalay Irit
Ben-Neriah Yinon
Ciechanover Aaron
Manning Anthony
Mercurio Frank
Degen Nancy
Signal Pharmaceuticals Inc.
Yissum Research Development Company of the Hebrew University of
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