Compositions and methods for manipulating carbon flux in cells

Details Compositions and methods for manipulating carbon flux in cells Compositions and methods for manipulating carbon flux in cells

2009-03-23

2010-11-23

Raghu, Ganapathirama (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S252320, C435S252330, C435S252340, C435S254210, C435S254300, C435S254900, C435S255200, C435S471000, C435S483000, C435S486000, C435S487000, C435S183000, C435S193000, C536S023200, C536S024100

Reexamination Certificate

active

07838278

ABSTRACT:
Nucleotide and protein sequences that encode enzymes that change carbon flux through metabolic pathways that lead to lactic acid or fumarate production in a host cell, such as aR. oryzaecell, are provided. Methods of manipulating carbon flux in a cell also are provided.

REFERENCES:
patent: 6171833 (2001-01-01), Sinskey et al.
patent: 6403351 (2002-06-01), Sinskey et al.
patent: 6884606 (2005-04-01), Sinskey et al.
patent: 6965021 (2005-11-01), Hanke et al.
patent: 7300777 (2007-11-01), Hanke et al.
patent: 7566563 (2009-07-01), Fatland-Bloom et al.
Broun et al., Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids. Science, 1998, vol. 282: 1315-1317.
Devos et al., Practical limits of function prediction. Proteins: Structure, Function, and Genetics. 2000, vol. 41: 98-107.
Seffernick et al., Melamine deaminase and Atrazine chlorohydrolase: 98 percent identical but functionally different. J. Bacteriol.,2001, vol. 183 (8): 2405-2410.
Whisstock et al., Prediction of protein function from protein sequence. Q. Rev. Biophysics., 2003, vol. 36 (3): 307-340.
Witkowski et al., Conversion of b-ketoacyl synthase to a Malonyl Decarboxylase by replacement of the active cysteine with glutamine. Biochemistry, 1999, vol. 38: 11643-11650.
McKinlay, James B. et al., “Prospects for a bio-based succinate industry”, Applied Microbiology. and Biotechnology (2007) 76:727-740.
Stucka, Rolf et al., “DNA sequences in chromosomes II and VII code for pyruvate carboxylase isoenzymes inSaccharomyces cerevisiae: analysis of pyruvate carboxylase-deficient strains”, Molecular Genetics & Genomics (1991) 229:307-315.
Potera, Carol, “Making Succinate More Successful”, Environmental Health Perspectives, vol. 113, No. 12, Dec. 2005, A832-A835.
Magnuson, Jon K. et al., “Organic Acid Production by Filamentous Fungi”, Pacific Northwest National Laboratory, pp. 307-340, Adv. Fungal Biotechnol., 2004.
Goldberg, Israel et al., Organic acids: old metabolites, new themes, Journal of Chemical Technology and Biotechnology 81:1601-1611 (2006).
Engel, Carol A. et al., “Fumaric acid production by fermentation”, Applied Microbiology and Biotechnology (2008) 78:379-389.

Affiliated with

Also associated with

Rating

Compositions and methods for manipulating carbon flux in cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for manipulating carbon flux in cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for manipulating carbon flux in cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4251838