Compositions and methods for lowering cholesterol while maintain

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills

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424451, 424489, 514824, A61K 914, A61K 920, A61K 948

Patent

active

056629346

ABSTRACT:
Compositions comprising a physiologically-acceptable antioxidant and a cholesterol-lowering agent for treating hypercholesterolemia and the accompanying lowering of antioxidant levels in an individual are disclosed. A preferred composition for use in reducing serum cholesterol levels while maintaining antioxidant levels in an individual comprises beta-carotene and gemfibrozil (LOPID.RTM.).

REFERENCES:
patent: 5278189 (1994-01-01), Rath et al.
Harris, William S., Ph.D., "The Prevention of Atherosclerosis with Antioxidants", Clin. Cardiol., (1992), vol. 15, pp. 636-640.
Kalyanaraman, B., et al., "Synergistic Interaction between the Probucol Phenoxyl Radical and Ascorbic Acid in Inhibiting the Oxidation of Low Density Lipoprotein", The Journal of Biological Chemistry, (1992), vol. 267, No. 10, pp. 6789-6795.
Fruchart, J.C., "LDL et Atherogenese: Nouveaux Concepts", Sem Hop Paris, (1989), vol. 65, No. 3, pp. 91-95.
Blickle, J.F., et al., "Le Traitement des Hypercholesterolemies: Aspects Recents", J. Med. Strasbourg, (1990), vol. 21, No. 10 pp. 580-583.
Finckh, B., et al., "Antiatheroslerotic Effect of Probucol in WHHL Rabbits: Are there Plasma Parameters to Evaluate this Effect?", Eur. J. Clin. Pharmacol., (1991), vol. 40 [Supp. 1], pp. S77-S80.
Manninen, Vesa, M.D., et al., "Lipid Alterations and Decline in the Incidence of Coronary Heart Disease in the Helsinki Heart Study", Jama, (1988), vol. 260, No. 5, pp. 641-651.
Fruchart, J.C., "Antioxidant Therapy and Uptake of Human Oxidized LDL by Macrophages", Annals, New York Academy of Sciences, (1989), vol. 570, pp. 447-448.
Albanes et al. "Serum beta-carotene before and after beta-carotene supplementation" European Journal of Clinical Nutrition 1992, vol. 46, pp. 15-24, received Mar. 28, 1991; accepted Jun. 27, 1991.
Chisolm G.M. "Antioxidants and Atherosclerosis: A Current Assessment" Clinical Cardiology 1991, vol. 14, pp. I-25-30.
The Lipid Research Clinics Investigators "The Lipid Research Clinics Coronary Primary Prevention Trail; Results of 6 years of Post-Trial Follow-up" Archives Internal Medicine Original Investigation 1992, vol. 152, pp. 1399-1410.
Heady et al. "WHO clofibrate/cholesterol trail: clarifications" The Lancet Letters to the Editor 1992,vol. 340, pp. 1405-1406.
Marenah et al. "Hypocholesterolaemia and non-cardiovascular disease: metabolic studies on subjects with low plasma cholesterol concentrations" British Medical Journal 1983, vol. 286, pp. 1603-1606.
Potischman et al. "Associations Between Breast Cancer, Plasma Triglycerides,and Cholesterol" Nutrition and Cancer 1991, vol. 15, pp. 205-215.
DeRijke et al. "Susceptibility of low-density lipoproteins to oxidation in coronary bypass patients" The Lancet 1992, vol. 340, Oct. 3.
Associated Press "Vitamin E Seems to Benefit Heart, 2 Studies Show" The New York Times National Thursday, Nov. 19, 1992.
Stahelin et al. "Plasma Antioxidant Vitamins and Subsequent Cancer Mortality in the 12-Year Follow-up of the Prospective Base Study" American Journal Epidemiology 1991, vol. 133, No. 8, pp. 766-775.
Strejan et al. "Suppression of Chronic-Relapsing Experimental Allergic Encephalomyelitis in Strain-13 Guinea Pigs by Administration of Liposome-Associated Myelin Basic Protein" Journal of Neuroimmunology 1984/85, vol. 7, pp. 27-41.

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