Compositions and methods for interfering wtih hepatitis B virus

Details Compositions and methods for interfering wtih hepatitis B virus Compositions and methods for interfering wtih hepatitis B virus

1994-10-06

1999-02-16

Knode, Marian C.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

530324, 530326, 530350, 530412, A61K 3800, C07K 200

Patent

active

058722068

ABSTRACT:
The invention provides for compositions and methods for interfering with Hepatitis B viral infection that are based on the interaction of Hepatitis B virus X protein with a novel proteasome subunit.

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patent: 5425942 (1995-06-01), Tanaka
Fischer et al., Virus Genes 10:1, 99-102 (995).
Huang et al., AASLD Abstracts: Hepatology vol. 20(4), p. 305A Abstract 833 (1994).
Fischer et al., "HBx Protein of Hepatitis B Virus Interacts with the C-Terminal Portion of a Novel Human Proteasome Alpha-Subunit", Virus Genes 10, 99-102, 1995.
Maguire et al., "HBV X Protein Alters the DNA Binding Specificity of CREB and ATF-2 by Protein-Protein Interactions", Science 252, 842-844, 1991.
Rock et al., "Inhibitors of the Proteasome Block the Degradation . . . ", Cell 78:761-771, Sep. 9, 1994.
Fehling et al., "MHC Class I Expression in Mice Lacking the Proteasome Subunit LMP-7", Science 265:1234-1237, Aug. 26, 1994.
Pugh et al., "Expression of the X Gene of Hepatitis B Virus", J. Med. Virol. 20:229-246 (1989).
Bichko et al., "Subtype ayw variant of hepatitis B virus", FEBS Lett. 185, 208-212 (1985).
Srikumar et al., "Immunological Properties of Recombinant Porin of Haemphilus inflenzae Type b Expressed in Bacillus Subtillis", Infection and Immunity 61 (8), 3334-3341 (1993).

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