Compositions and methods for inhibition of phospholipase A2...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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Details

C514S563000, C562S015000, C562S450000, C562S553000

Reexamination Certificate

active

07745489

ABSTRACT:
Specific, highly potent 2-oxo-amide based inhibitors of phospholipase A2(PLA2) activity are provided. A role for PLA2activity in spinally mediated inflammatory processes is established, and a method for treating hyperalgesia and other inflammatory conditions associated with PLA2activity is provided.

REFERENCES:
patent: 5089492 (1992-02-01), Gerling et al.
patent: 5889040 (1999-03-01), Beale et al.
patent: 48004421 (1971-05-01), None

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