Compositions and methods for inhibiting Yersinia pestis...

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

Reexamination Certificate

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C435S340000

Reexamination Certificate

active

07863425

ABSTRACT:
The invention provides a gene transfer vector for inducing an immune response againstYersinia pestisin a mammal. The gene transfer vector comprises a nucleic acid sequence encoding an immunogenic portion of one or more proteins ofYersinia pestisand/or a nucleic acid sequence encoding a monoclonal antibody directed againstYersinia pestis. The invention further provides a method of producing an immune response againstYersinia pestisin a mammal comprising administration of the gene transfer vector to the mammal. The invention also provides a monoclonal antibody directed against the Virulence (V) antigen ofY. pestis, as well as a hybridoma cell line producing same and a nucleic acid sequence encoding same.

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