Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-10-06
1998-04-28
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 21, 536122, 5361231, 514 54, 514921, A61K 31725, C08B 3710
Patent
active
057444579
ABSTRACT:
The present invention provides compositions and methods for inactivating thrombin bound to fibrin within a thrombus or clot, whereby the ability of clot-bound thrombin to catalytically promote further clot accretion is substantially diminished or eliminated. The compositions and methods of the present invention are particularly useful for preventing thrombosis in the circuit of cardiac bypass apparatus and in patients undergoing renal dialysis, and for treating patients suffering from or at risk of suffering from thrombus-related cardiovascular conditions, such as unstable angina, acute myocardial infarction (heart attack), cerebrovascular accidents (stroke), pulmonary embolism, deep vein thrombosis, arterial thrombosis, etc.
REFERENCES:
patent: 4281108 (1981-07-01), Fussi
patent: 4351938 (1982-09-01), Barnett
patent: 4496550 (1985-01-01), Lindahl et al.
patent: 4500519 (1985-02-01), Lormeau et al.
patent: 4629699 (1986-12-01), Bianchini
patent: 4687765 (1987-08-01), Vairel et al.
patent: 4791195 (1988-12-01), Bianchini
patent: 4847338 (1989-07-01), Linhardt et al.
patent: 4916219 (1990-04-01), Linhardt et al.
patent: 4933326 (1990-06-01), Bianchini et al.
patent: 4942156 (1990-07-01), Foley et al.
patent: 4981955 (1991-01-01), Lopez
patent: 4990502 (1991-02-01), Lormeau et al.
patent: 5010063 (1991-04-01), Piani et al.
patent: 5013724 (1991-05-01), Petitou et al.
patent: 5019649 (1991-05-01), Lormeau et al.
patent: 5084564 (1992-01-01), Vila et al.
patent: 5106734 (1992-04-01), Nielsen
patent: 5236910 (1993-08-01), Egidio et al.
patent: 5547944 (1996-08-01), Mascellani et al.
Shimotori et al. Seminars in Thrombosis and Hemostasis 1990, 16 Supplement, 71-76. Month not available.
Nagase et al. Blood Mar. 15, 1995, 85(6), 1527-1534.
Weitz et al. J. Lab. Clin. Med. 1993, 122(4), 364-373. Month not available.
Linhardt et al. J. Med. Chem. 1990, 33, 1639-1645. Month not available.
Jordan et al.J. Biol. Chem. 1980, 255(21), 10081-10090. Month not available.
Tollefsen et al. Seminars in Thrombosis and Hemostasis 1990, 16 Supplement, 66-70. Month not available.
Alhenc-Gelas, et al., "Laboratory Control of Low-Molecular-Weight Heparins: Needs and Possibilities," Fundamental and Clinical Cardiology, 19:43-54 (1994), no month available.
Atha, et al., "Physicochemical Characterization of Low Molecular Weight Heparin," J. Pharm. Sciences, 84 (3) :360-364 (1995), no month available.
Barzu, et al., "O-Acylated heparin derivatives with low anticoagulant activity decrease proliferation and increase .alpha.--smooth muscle active expression in cultured arterial smooth muscle cells," Euro. J. Pharm., 219:225-233 (1992), no month available.
Barzu, et al., "Preparation and Anti-HIV Activity of O-Acylated Heparin and Dermatan Sulfate Derivatives with Low Anticoagulant Effect," J. Med. Chem., 36:3546-3555 (1993), no month available.
Cifonelli, et al., "The Distribution of 2-Acetamido-2-Deoxy-D-glucose residues in Mammalian Heparins," Charbo. Res., 21:173-186 (1972), no month available.
Doctor, et al., "Anticoagulant Properties of Semisynthetic Polysaccharide Sulfates," Thrombosis Research, 64:413-425 (1991), no month available.
Horton, et al., The Nitrous Acid Deamination of Glycosides and Acetates of 2-Amino-2-Deoxy-D-Glucose, Charbo. Res., 30:367-374 (1973), no month available.
Lagunoff, et al., "Determination of 2-Deopxy-2-Sulfoaminohexose Content of Mucopolysaccharides," Archives of Biochem. and Biophys., 99:396-400 (1962), no month available.
Mascellani, et al., Active Sites of Dermatan Sulfate for Heparin Cofactor II. Isolation of a Nonasaccharide Fragment Containing Four Disaccharide (1,3)-.beta.-D-N-Acetylgalactosamine 4-Sulfate!, J. Carbohydrate Chem., 14 (8):1165-1177 (1995), no month available.
Mattsson, et al., "Antithrombotic Effects of Heparin Oligosaccharides," Annals of the N.Y. Acad. Sci., 556:323-332 (1989), no month available.
Schoen, et al., "The Effect of Sulfation of the Anticoagulant and Antithrombin III-Binding Properties of a Heparin Fraction with Low Affinity for Antithrombin III," Thrombosis Research, 57:415-423 (1990), no month available.
Shively, et al., "Formation of Anhydrosugars in the Chemical Depolymerization of Heparin," Biochemistry, 15(18):3932-3942 (1976), no month available.
Shively, et al., "Nearest Neighbor Analysis of Heparin: Identification and Quantitation of the Products Formed by Selective Depolymerization Procedures," Biochemistry, 15(18):3943-3950 (1976), no month available.
Shively, et al., "Stoichiometry of the Nitrous Acid Deaminative Cleavage of Model Amino Sugar Glycosides and Glycosaminoglycuronans," Biochemistry, 9(1):33-43 (1970), no month available.
Svahn, et al., "Inhibition of angiogenesis by heparin fragments in the presence of hydrocortisone," Carbohydrate Polymers, 18:9-16 (1992) no month available.
Tollefsen, et al., "Effect of Low Molecular Weight Heparin Preparations on the Inhibition of Thrombin by Heparin Cofactor II, " Seminars in Thrombosis and Hemostasis, 16 (supp.):66-70, no month available.
Cade, et al., "A Comparison of the Antithrombotic and Haemorrhagic Effects of Low Molecular Weight Heparin Fractions: The Influence of the Method of Preparation," Thrombosis Research, 35:613-625 (1984), month not available.
Hirsh Jack
Weitz Jeffrey I.
Young Edward
Fonda Kathleen K.
Hamilton Civic Hospitals Research Development Inc.
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