Compositions and methods for inhibiting the action of androgens

Details Compositions and methods for inhibiting the action of androgens Compositions and methods for inhibiting the action of androgens

1986-03-27

1987-08-04

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514171, 514175, 514177, 514178, A61K 3156

Patent

active

046846352

ABSTRACT:
Synergistic compositions for inhibiting the action of androgens comprise the combination in a single topical preparation of a 5.alpha.-reductase enzyme inhibitor and an androgen receptor blocking agent in a pharmaceutically and dermatologically acceptable vehicle. The compositions may be topically applied to affected areas of the skin in the treatment or prevention of sebaceous gland hypertrophy, hirsutism and male-pattern baldness in mammals. The inhibitor and blocking agent are present in the composition in a weight ratio of about 1:20 to 5:1, with the inhibitor comprising up to about 0.1% w/v of the composition and the blocking agent comprising up to about 1% w/v of the composition.

REFERENCES:
patent: 4347245 (1982-08-01), Shapiro
Federal Register, vol. 45--No. 218 (1980), pp. 73955-73960.
Federal Register, vol. 50, No. 10 (1985), pp. 2190-2198.
J. S. Strauss, "Hormones and the Pilosebaceous Apparatus," Hair Research (1981), 223-228.
A. Schleusener et al., "Pharmacology of Old and New Antiandrogens," Androgens and Anti-Androgen Therapy (1981), 71-93.
J. M. Beazley et al., "Skin Metabolism," Androgens and Anti-Androgen Therapy (1982), 41-69.
J. Girard et al., "Inhibition of Testosterone Metabolism" 269 Arch Dermatol. Res. (1981), 281-290.
N. Orentreich et al., "Biology of Scaly Hair Growth," 9 Clinics in Plastic Surgery (1982), 197-205.
R. Aron-Brunetiere, "Aspects of Endocrinological Treatment," Hair Research (1981), 312-317.
J. R. Rentoul, "Management of the Hirsuite Woman," 22 Int'l J. of Derm. (1983), 265-272.
P. G. Nielsen, "Treatment of Moderate Idiopathic Hirsutism," 165 Dermatologica (1982), 636-639.
F. Neuman et al., "Central Actions of Antiandrogens," Androgens and Antiandrogens (1977), 163-177.
F. J. Ebling, "Antiandrogens and Dermatology," Androgens and Antiandrogens (1977), 341-349.
W. I. P. Mainwaring, "Modes of Action of Antiandrogens," Androgens and Antiandrogens (1977), 151-161.
J. P. Raynaud et al., "Present Trends in Antiandrogen Research," Androgens and Antiandrogens (1977), 281-293.
A. L. Southren et al., "Effect of Progestagens," Androgens and Antiandrogens (1977), 267-279.

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