Compositions and methods for inhibiting replication of human imm

Details Compositions and methods for inhibiting replication of human imm Compositions and methods for inhibiting replication of human imm

1993-06-03

1997-08-05

Guzo, David

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

11 to 14 amino acid residues in defined sequence

530328, C07K 706

Patent

active

056543980

ABSTRACT:
Compositions and methods for identifying compositions which inhibit binding of the Rev protein to the Rev-responsive element in cells infected by HIV-1 are provided. The compositions display or mimic the electronic configuration of a binding domain within the native Rev protein, but are free from those portions responsible for REV activity and are preferably modified to display enhanced binding affinity to the RRE. Screening methods for identifying polypeptides and other compositions having such enhanced binding affinity are also described.

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Tiley et al. (1992), Proc. Natl. Acad. Sci. USA, 89:758-762.
Chin (1992), Journal of Virology, pp. 600-607.
Heaphy et al. (1991), Proc. Natl. Acad. Sci. USA, 88:7366-7370.
Kjems et al. (1991), Cell, 67:169-178.
Kjems et al. (1992), EMBO Journal, 3:1119-1129.

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