Compositions and methods for inhibiting nematocyst discharge

Details Compositions and methods for inhibiting nematocyst discharge Compositions and methods for inhibiting nematocyst discharge

1997-05-29

2000-10-17

Dodson, Shelley A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Biocides; animal or insect repellents or attractants

424 59, 424400, 424401, 424677, 424681, 514579, 514651, 514829, 514862, A01N 2500, A61K 900, A61K 700, A61K 742

Patent

active

061327476

ABSTRACT:
Compositions for inhibiting nematocyst or polar capsule discharge are provided in the form of an effective amount of antihistamine or an effective amount of antihistamine and an effective amount of at least one cation. The compositions can be in the form of ointments or can be added to the environment surrounding the nematocysts or polar capsules. Methods of inhibiting nematocyst or polar capsule discharge using the compositions of the invention are also provided.

REFERENCES:
patent: 4234566 (1980-11-01), Packman et al.
patent: 4873265 (1989-10-01), Blackman
patent: 4929619 (1990-05-01), Blackman
Shiomi et al. "Inhibitory effect of anti-infalmmatory agents on cutaneous capillary leakage induced by six marine venoms", (Abstract), Nippon Suisan Gakkaishi, 55 (1), 131-4, 1989.
Salleo et al., "Gadolinium is a powerful blocker of the activation of Nematocytes of Pelagia noctiluca" J. Exp. Biol. 187:201-206 (1994).
Information regarding Beach-Aid.TM. from Bethurum R & D, http://www.Bethurum.com, 2 pages total. 1996.
Burnett, "Human injuries following jellyfish stings" MMJ (1992) 41(6):509-513.
El-Matbouli et al., "Light and electron microscopic observations on the route of the triactinomyxon-sporoplasm of Myxobolus cerebralis from epidermis into rainbow trout cartilage" J. Fish Biol. (1995) 46:919-935.
Fenner et al., "First aid treatment of jellyfish stings in Australia" Med. J. Aust. (1993) 158:498-501.
Gerke et al., "The spatial distribution of cations in nematocytes of Hydra vulgaris" Hydrobiologica (1991) 216/217:661-669.
Godknecht et al., "Discharge and mode of action of the tentacular nematocysts of Anemonia sulcata (Anthozoa: Cnidaria)" Marine Biol. (1988) 100:83-92.
Hartwick et al., "Disarming the box-jellyfish: Nematocyst inhibition in chironex fleckeri" Med. J. Aust. (1980) 1:15-20.
Heeger et al., "Protection of human skin against jellyfish (Cyanea capillata) stings" Marine Biol. (1992) 113:669-678.
Hidaka et al., "Effects of cations on the volume and elemental composition of nematocysts isolated from acontia of the sea anemone Calliactis polypus" Biol. Bull. (1993) 184:97-104.
Holstein et al., "Fibrous mini-collagens in hydra nematocysts" Science (1994) 265:402-404.
Holstein and Tardent, "An ultrahigh-speed analysis of exocytosis: nematocyst discharge" Science (1984) 223:830-833.
Lotan et al., "Life cycle of Rhopilema nomadica: a new immigrant scyphomedusan in the Mediterranean" Marine Biology (1992) 112:237-242.
Lotan et al., "Synchronization of the life cycle and dispersal pattern of the tropical invader scyphomedusan Rhopilema nomadica is temperature dependent" Mar. Ecol. Prog. Ser. (1994) 109:59-65.
Lotan et al., "Delivery of a nematocyst toxin" Nature (1995) 375:456.
Lotan et al., "Toxin Compartmentation and Delivery in the Cnidaria: The nematocyst's tubule as a multiheaded poisonous arrow" J. Exp. Zool. (1996) 275:444-451.
Lotan et al., "Toxinology and ecology of the Mediterranean jellyfish Rhopilema nomadica" Biochem. Aspects of Marine Pharm. (1996) eds. Lazrovici et al. (Alaken, Inc., Fort Collins, Colorado) pp. 132-144.
Lubbock, "Chemical recognition and nematocyte excitation in a sea anemone" J. Exp. Bio. (1979) 83:283-292.
Lubbock et al., "Novel role of calcium in exocytosis: Mechanism of nematocyst discharge as shown by x-ray microanalysis" Proc. Natl. Acad. Sci. USA (1981) 78(6):3624-3628.
Lubbock and Amos, "Removal of bound calcium from nematocyst contents causes discharge" Nature (1981) 290(5806):500-501.
Mariscal, "Nematocysts" Coelenterate Biology: Reviews and new perspectives, eds. Muscatine and Lenhoff (Academic Press, New York, 1974), pp. 129-179.
Russell et al., "Clinical articles seabather's eruption or "sea lice": New findings and clinical implications" Print-out from Florida Atlantic University World Wide Web site (1995) http://www.fau.edu/safe/sea-lice.html, 7 pages total.
Smothers et al., "Molecular evidence that the myxozoan protists are metazoans" Science (1994) 265:1719-1721.
Spaulding, "The life cycle of peachia quinquecapitata, an anemone parasitic on medusae during its larval development" Biol. Bull. (1972) 143:440-453.
Tardent, "The cnidarian cnidocyte, a high-tec cellular weaponry" BioEssays (1995) 17(4):351-362.
Thorington et al., "Control of Cnida discharge: I. Evidence for two classes of chemoreceptor" Biol. Bull. (1988) 174:163-171.
Thorington et al., "Control of discharge: Factors affecting discharge of Cnidae" The Biology of Nematocysts, Academic Press, Inc. (1988) pp. 233-253.
Tomchik et al., "Clinical perspectives on seabather's eruption, also known as `sea lice `" JAMA (1993) 269(13):1669-1672.
Vaitukaitis, "Production of Antisera with Small Doses of Immunogen: Multiple Intradermal Injections" Methods in Enzymology, vol. 73, ed. Larson and Vunkis (Academic Press, New York, 1981), pp. 46-52.
Wasuwat, "Extract of Ipomoea pes-caprae (Convolvulaceae) antagonistic to histamine and jelly-fish poison" Nature (1970) 225:758.
Watson, "Ultrastructure and cytochemistry of developing nematocysts" The Biology of Nematocysts, Academic Press, Inc. (1988) pp. 143-164.
Watson et al., "Cnidocyte mechanoreceptors are tuned to the movements of swimming prey by chemoreceptors" Science (1989) 243:1589-1591.
Weber et al., "Nematocysts (stinging capsules of Cnidaria) as Donnan-potential-dominated osmotic systems" Int. J. Biochem. (1989) 184:465-476.
Yokoyama et al., "Some biological characteristics of actinosporeans from the oligochaete Branchiura sowerbyi" Dis. aquat. Org. (1993) 17:223-228.
Yokoyama et al., "Chemoresponse of actinosporean spores of Myxobolus cultus to skin mucus of goldfish Carassius auratus" Dis. aquat. Org. (1995) 21:7-11.

Affiliated with

Also associated with

Rating

Compositions and methods for inhibiting nematocyst discharge does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for inhibiting nematocyst discharge, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inhibiting nematocyst discharge will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-465884