Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Reexamination Certificate
2005-12-27
2005-12-27
Celsa, Bennett (Department: 1639)
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
C514S002600, C514S013800, C530S300000, C530S326000
Reexamination Certificate
active
06979572
ABSTRACT:
The present invention provides compounds and methods of identifying and designing compounds which inhibit activity of inward-rectifier K+channels. In particular, compounds having a tertiapin-like α helix, such as a stable tertiapin derivative wherein the methionine residue in position 13 of tertiapin is replaced by glutamine, are described. Methods of using these compounds to control insulin secretion, and cardiac rhythm and electrical conduction, to modulate neurotransmissions of neurons, and to induce diuresis in mammals are also provided.
REFERENCES:
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Hider et al., “A comparative Stgructural Study of Apamin and Releated Bee Venom Peptides”,Biochemica Biophysica Acta.1981 667:197-208 [0006-3002].
Celsa Bennett
Licata & Tyrrell P.C.
Trustees of the University of Pennsylvania
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