Compositions and methods for inhibiting human immunodeficiency v

Details Compositions and methods for inhibiting human immunodeficiency v Compositions and methods for inhibiting human immunodeficiency v

1997-06-02

2000-06-06

Degen, Nancy

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4353201, 435366, 536 231, 536 245, C12N 1585, C12N 1563, C07H 2104

Patent

active

060717432

ABSTRACT:
The present invention relates to the identification of several human genes as cellular targets for the design of therapeutic agents for suppressing human immunodeficiency virus (HIV) infection. These genes encode intracellular products which appear to be necessary for HIV replication, as evidenced by an inhibition of HIV infection in cells in which the expression of these genes is down-regulated. Therefore, inhibitors of these genes and their encoded products may be used as therapeutic agents for the treatment and/or prevention of HIV infection. In addition, the invention also relates to methods for identifying additional cellular genes as therapeutic targets for suppressing HIV infection, and methods of using such cellular genes and their encoded products in screening assays for selecting additional inhibitors of HIV.

REFERENCES:
patent: 5256534 (1993-10-01), Butera et al.
Rojanasakul et al., Antisense oligonucleotide therapeutics: drug delivery and targeting, Advanced Drug Delivery Reviews, vol. 18, pp. 115-131, 1996.
Gewirtz et al., Facilitating oligonucleotide delivery: helping antisense deliver on its promise, Proc. Natl. Acad. Sci., vol. 93, pp. 3161-3163, Apr. 1996.
Branch, A good antisense molecules is hard to fing, TIBS, vol. 23, pp. 45-50, Feb. 1998.
Folks et al., Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone, Proc. Natl. Acad. Sci., vol. 86, pp. 2365-2368, Apr. 1989.
Antisense '97: A roundtable on the state of the industry, Nature Biotechnology, vol. 15, pp. 519-524, Jun. 1997.
Hayasaka. GenBank. Accession # D38112, Apr. 1996.
Marzuki. GenBank. Accession # X62996, Aug. 1992.
Koike et al. GenBank. Accession # D10523, Sep. 1995.
Tani et al. GenBank. Accession # M23725, Sep. 1992.
Galvin et al. GenBank. Accession # M98452, Sep. 1992.
Hillier et al. GenBank. Accession # H38436, Aug. 1995.
Barre-Sinoussi et al., 1983, Science 220:868-870.
Gallo et al., 1984, Science 224:500-503.
Teich et al., 1984 RNA Tumor Viruses, Weiss et al., eds., CSH-Press, Pp. 949-956.
Varmus, 1988, Science 240:1427-1439.
Clavel et al., 1986, Science 233:343-346.
Guyader et al., 1987, Nature 326:662-669.
Dalgleish et al., 1984, Nature 312:763-767.
Klatzman et al., 1984, Nature, 312:767-768.
Maddon et al., 1986, Cell 47:333-348.
Smith et al., 1986, Science 232:382-385.
Mitsuya et al., 1991, FASEB J. 5:2369-2381.
Larder et al., 1989, Science 243:1731-1734.
Smith et al., 1987, Science 238:1704-1707.
Daar et al., 1990, Proc. Natl. Acad. Sci. USA 87:6574-6579.
Schooley et al., 1990, Ann. Int. Med. 112:247-253.
Kahn et al., 1990, Ann. Int. Med. 112-254-261.
Yarchoan et al., 1989, Proc. Vth Int. Conf. on AIDS, p. 564, MCP 137.
Erickson, 1990, Science, 249:527-533.
Ventakash et al., 1990, Proc. Natl. Acad. Sci. USA 87:8746-8750.
Brady et al., 1994, Proc. Natl. Acad. Sci. USA 91:365-369.
Malim et al., 1992, J. Exp. Med. 176:1197.
Bevec et al., 1992, Proc. Natl. Acad. Sci. USA 89:9870-74.
Woffendin et al., 1994, Proc. Natl. Acad. Sci. USA 91:11581-85.
Lee et al., 1994, J. Virology 68:8254-64.
Marasco et al., 1993, Proc. Natl. Acad. Sci. USA 90:7889-93.
Chatterjee et al., 1992, Science 258:1485.
Ojwang et al., 1992 Proc. Natl. Acad. Sci. USA 89:10802-06.
Yamada et al., 1994, Gene Therapy 1:38-45.
Miller and Rosman, 1989, BioTechniques 7:980.
Miller and Buttimore, 1986, Mol. Cell. Biol. 6:2895-2902;ATCC CRL #9078.
Bednarkik and Folks, 1992, AIDS 6:3-16.
Poli and Fauci, 1992, AIDS Res. Human Retroviruses 9:191-197.
Foley et al., 1965, Cancer 18:522-29.
Nara & Fischinger, 1988, Nature 322:469-70.
Bittner et al., 1987, Methods in Enzymool. 153:516-544.
Logan & Shenk, 1984, Proc. Natl. Acad. Sci. USA 81:3655-3659.

Affiliated with

Also associated with

Rating

Compositions and methods for inhibiting human immunodeficiency v does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Compositions and methods for inhibiting human immunodeficiency v, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Compositions and methods for inhibiting human immunodeficiency v will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2212245