Compositions and methods for inhibiting expression of factor...

Details Compositions and methods for inhibiting expression of factor... Compositions and methods for inhibiting expression of factor...

2011-01-18

2011-01-18

McGarry, Sean (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S024300, C536S024330, C536S024500

Reexamination Certificate

active

07871985

ABSTRACT:
The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the Factor VII gene.

REFERENCES:
Geisbert et al. (The Lancet, 2003 vol. 362:1953-1958).
Kim, Dong-Ho et al., “Synthetic dsRNA dicer substrates enhance RNAi potency and efficacy,” Nature Biotechnology, Dec. 26, 2004, pp. 222-226, vol. 23, No. 2, Nature Publishing Group, New York, New York.
Matthias, J. et al., “Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway,” Nature (London), Oct. 11, 2007, pp. 745-748, vol. 449, four pages.
Wallin, R. et al., “Enhanced Synthesis of Functional Recombinant Factors IX and VII by BHK Cells Engineered to Overexpress VKORC1 Combined with siRNA Silencing of the Gamma-carboxylation Inhibitor Calumenin,” Blood (ASH Annual Meeting Abstracts) 2006, vol. 108, one page.
PCT Invitation to Pay Additional Fees, PCT Application No. PCT/US2008/086158, Apr. 8, 2009.
PCT International Search Report and Written Opinion, PCT Application No. PCT/US2008/086158, Jun. 10, 2009.

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